Anti-C1RL Antibody

Product Name

Anti-C1RL Antibody

View all Complement Component C1rLP Antibodies

SKU/Catalog Number

A10694

Size

100ul

Form

Liquid

Description

Boster Bio Anti-C1RL Antibody catalog # A10694. Tested in ELISA, WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-C1RL Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10694)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human C1RL.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A10694 is reactive to C1RL in Human

Applications

A10694 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

53.498kDa

Background of Complement Component C1rLP

Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development By similarity.

Scherer S.E., Nature 440:346-351(2006).
Danilova N., Brain Res. Dev. Brain Res. 153:115-119(2004).
Ota T., Nat. Genet. 36:40-45(2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB 1:500-2000
ELISA 1:10000-20000

Validation Images & Assay Conditions

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Figure 1. Western blotting validation for Anti-C1RL Antibody A10694

Western Blot analysis of hela cells using primary antibody diluted at 1:500 (4°C overnight). Secondary antibody:Goat Anti-rabbit IgG IRDye 800 (diluted at 1:5000

Gene/Protein Information For C1RL (Source: Uniprot.org, NCBI)

Alternative Names

C1RL; C1RL1; C1RL1complement C1r subcomponent-like protein; C1r-like protein; C1r-like serine protease analog protein; C1r-LPcomplement C1r-like proteinase; C1RLPEC 3.4.21.-; CLSPa; complement component 1, r subcomponent-like; Complement Component C1rLP; EC 3.4.21; EC 3.4.21.41 C1RL C1RL1P, C1r-LP, CLSPa, C1RL complement C1r subcomponent like complement C1r subcomponent-like protein|C1r-like protein|C1r-like serine protease analog protein|complement C1r-like proteinase|complement component 1, r subcomponent-like

For more info on C1RL, check out the C1RL Infographic

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In this infographic, you will see the following information for C1RL: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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