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Product Info Summary
| SKU: | A02384 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, ICC, WB |
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Product info
Product Name
Anti-Caspase-2 CASP2 Antibody
SKU/Catalog Number
A02384
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Caspase-2 CASP2 Antibody (Catalog # A02384). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse.
Storage & Handling
Caspase-2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Caspase-2 CASP2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02384)
Host
Rabbit
Contents
Caspase-2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Caspase-2 antibody was raised against a 16 amino acid synthetic peptide from the amino-terminus of human Caspase-2. The immunogen is located within the first 50 amino acids of Caspase-2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Depending on cell lines or tissues used, other cleavage products may be observed.
Reactive Species
A02384 is reactive to CASP2 in Human, Mouse
Applications
A02384 is guaranteed for ELISA, ICC, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
50.685kDa
Background of Caspase-2
Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Although phylogenetically similar to this subfamily, Caspase-2 is thought to be involved in stress-induced apoptosis. Caspase-2 has two major isoforms; overexpression on the long form results in apoptosis while that of the short form suppresses cell death.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Caspase-2 antibody can be used for the detection of caspase-2 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 2 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Caspase-2 in (A) human thymus tissue and (B) human kidney lysate with Caspase-2 antibody at 1 μg/mL.
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Immunocytochemistry of caspase-2 in A-20 cells with caspase-2 antibody at 2 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For CASP2 (Source: Uniprot.org, NCBI)
Gene Name
CASP2
Full Name
Caspase-2
Weight
50.685kDa
Superfamily
peptidase C14A family
Alternative Names
caspase-2; CASP2; CASP-2; caspase 2, apoptosis-related cysteine peptidase; Caspase2; Caspase-2; ICH1; ICH-1; NEDD2; NEDD-2; PPP1R57 CASP2 CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57 caspase 2 caspase-2|caspase 2 apoptosis-related cysteine peptidase|neural precursor cell expressed developmentally down-regulated protein 2|protease ICH-1|protein phosphatase 1, regulatory subunit 57
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CASP2, check out the CASP2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CASP2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Caspase-2 CASP2 Antibody (A02384)
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No publications found for A02384
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Customer Reviews
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