- Table of Content
Associates with PIDD1 and CRADD to form the PIDDosome, a complex that triggers CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). .
|peptidase C14A family|
|Sequence:||7; NC_000007.14 (143288351..143307696)|
Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.
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