Caspase-2 (CASP2)

Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321).

Associates with PIDD1 and CRADD to form the PIDDosome, a complex that triggers CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). .