Caspase-2 Antibodies

AND CASP2 ELISA kits, Caspase-2 Proteins

Many biological assays use antibodies to detect Caspase-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Caspase-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Caspase-2 antibodies...

We validate the specificity of these antibodies to Caspase-2 by testing them on tissues known to express CASP2 positively and negatively. Browse below to find the CASP2 antibody that suites your experiment. We have 10 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CASP2 Infographic by Boster Bio

All CASP2 Products

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Specificity

Applications

Price

Anti-Caspase-2/CASP2 Antibody Picoband®

1 Q&As

Anti-Caspase-2 Picoband antibody, PB9368, Western blotting
All lanes: Anti Caspase-2 (PB9368) at 0

Human, Mouse, Rat

$370
Cat # PB9368
100 μg/vial

Anti-Caspase-2/CASP2 Antibody Picoband®

4 Q&As

Anti-Caspase-2 antibody, PA1113, Western blottingLane 1: CEM Cell LysateLane 2: SMMC Cell Lysate

Human, Mouse, Rat

$370
Cat # PA1113
100 μg/vial

Anti-Caspase-2 CASP2 Rabbit Monoclonal Antibody

Western blot analysis of Caspase-2 expression in Jurkat cell lysate

All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature

Immunohistochemical analysis of paraffin-embedded mouse testis, using Caspase-2 Antibody

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M02384-1
100 μl

Anti-Caspase-2 CASP2 Rabbit Monoclonal Antibody

Western blot analysis of Caspase-2 expression in HeLa cell lysate

Human, Mouse, Rat

$370
Cat # M02384
100 μl

Anti-Caspase-2/CASP2 Antibody Picoband®

Western blot analysis of Caspase-2 using anti-Caspase-2 antibody (A02384-1)

IHC analysis of Caspase-2 using anti-Caspase-2 antibody (A02384-1)

Human, Mouse, Rat

ELISA, IHC, WB

$370
Cat # A02384-1
100 μg/vial

Caspase 2 Colorimetric Cell-Based ELISA Kit

Western blot analysis of extracts from K562

Human

ELISA

$480
Cat # EKC1085
1 kit, containing one 96-well plate and all necessary reagents

Anti-Caspase-2 CASP2 Antibody

Western blot analysis of Caspase-2 in (A) human thymus tissue and (B) human kidney lysate with Caspase-2 antibody at 1 μg/mL

Immunocytochemistry of caspase-2 in A-20 cells with caspase-2 antibody at 2 μg/mL

Human, Mouse

ELISA, ICC, WB

$481
Cat # A02384
0.1 mg

Anti-Cleaved-Caspase-2 p18 (T325) CASP2 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A02384T325
100ul

Anti-Phospho-Caspase-2 (S157) CASP2 Antibody

Human, Mouse, Rat

ELISA, IF, IHC

$380
Cat # A02384S157
100ul

Human Caspase-2 Recombinant Protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain

SDS-PAGE, Denatured

$250
Cat # PROTP42575
Starting from 20ug

CASP2 Overview

Facts about Caspase-2.

CASP2 3D structure. Source: alphafold

Caspase-2 (CASP2)

Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321).

Associates with PIDD1 and CRADD to form the PIDDosome, a complex that triggers CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). .

Gene Information

Human
Gene Name:	CASP2
Uniprot:	P42575
Entrez:	835

Family

Belongs to:

peptidase C14A family

Alternative Names

caspase-2; CASP2; CASP-2; caspase 2, apoptosis-related cysteine peptidase; Caspase2; Caspase-2; ICH1; ICH-1; NEDD2; NEDD-2; PPP1R57

Molecular Weight

Mass (kDA):
50.685 kDA

Genomic Context


Human

Location:	7q34
Sequence:	7; NC_000007.14 (143288351..143307696)

Tissue Specificity

Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Leukemia
Blind Vision
Cell Transformation, Neoplastic
Malignant Paraganglionic Neoplasm
Melanoma
Lymphoma
Mammary Neoplasms
Ovarian Neoplasm
Prostatic Neoplasms

Neuroblastoma
Malignant Neoplasm Of Prostate
Tissue Adhesions
Hyperplasia
Malignant Neoplasm Of Breast
Metaplastic Cell Transformation

Interacting Proteins

CRADD

Pathways

Cell Death
Cell Cycle
Cell Proliferation
Programmed Cell Death
Induction Of Apoptosis
Pathogenesis
Protein Folding
Mitotic Catastrophe
Cell Cycle Checkpoint
Mitochondrial Depolarization
Inflammatory Response
Translation
Localization

Neuroprotection
Mismatch Repair
Drug Resistance
Cell Growth
Angiogenesis
Apoptotic Process
Autophagy

PTMs

Cleavage
Phosphorylation
Biotinylation

Ubiquitination
Reduction
Isgylation

Research Areas

Apoptosis
Cancer
Caspases

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CASP2

References

PMID: 8087842 by Wang L., et al. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death.

PMID: 11156409 by Droin N., et al. Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade.

27 Publications of Boster Caspase-2 Antibodies & ELISA Kits

PubMed ID: 22959511, Chen J, Wei H, Xie B, Wang B, Cheng J, Cheng J. Leuk Res. 2012 Dec;36(12):1526-3...
PubMed ID: 22848278, Chu Sh, Ma Yb, Feng Df, Zhang H, Qiu Jh, Zhu Za. Oncol Lett. 2011 Nov;2(6):1139-...
PubMed ID: 24700345, Zhao B, Li X. Oncol Rep. 2014 Jun;31(6):2769-75. Doi: 10.3892/Or.2014.3126. Epub...
PubMed ID: 25672487, Zhan W, Hu X, Yi J, An Q, Huang X. Mol Med Rep. 2015 Jun;11(6):4142-8. Doi: 10.3...
PubMed ID: 25344274, Huang C, Lin Y, Su H, Ye D. Neurochem Res. 2015 Jan;40(1):27-35. Doi: 10.1007/S1...
PubMed ID: 26064215, Kan S, Zhou H, Jin C, Yang H. Int J Clin Exp Med. 2015 Mar 15;8(3):3258-70. Ecol...
PubMed ID: 17589894, Wang Jm, Xiao Bl, Zheng Jw, Chen Hb, Zou Sq. World J Gastroenterol. 2007 Jun 21;...
PubMed ID: 22327753, Meng Qt, Xia Zy, Luo T, Cao C, Zhao B, Wu Y, Wu X, Chen X. Saudi Med J. 2012 Feb...
PubMed ID: 20920327, Zhou Y, Li W, Xu Q, Huang Y. J Exp Clin Cancer Res. 2010 Oct 4;29:131. Doi: 10.1...
PubMed ID: 22139054, Rasul A, Yu B, Khan M, Zhang K, Iqbal F, Ma T, Yang H. Int J Oncol. 2012 Apr;40(...
PubMed ID: 25736028, Peng X, Chen K, Chen J, Fang J, Cui H, Zuo Z, Deng J, Chen Z, Geng Y, Lai W. Env...
PubMed ID: 23559276, Chen J, Li X, Qiu J, You H, Zhang Q, Dong G, Zuo Y. Cell Biochem Biophys. 2013;6...
PubMed ID: 21479766, Liu Y, Zhou Y, Wang Y, Geng D, Liu J. Obes Surg. 2011 Sep;21(9):1424-31. Doi: 10...
PubMed ID: 24829152, Yang Y, Li Zh, Liu H, Shi Wd, Zhang J. Chin J Integr Med. 2015 Jun;21(6):423-30....
PubMed ID: 25074826, Song Gh, Wang Rl, Chen Zy, Zhang B, Wang Hl, Liu Ml, Gao Jp, Yan Xy. J Physiol B...
PubMed ID: 23810797, Chen K, Shu G, Peng X, Fang J, Cui H, Chen J, Wang F, Chen Z, Zuo Z, Deng J, Gen...
PubMed ID: 25206483, Mao Z, Song Z, Li G, Lv W, Zhao X, Li B, Feng X, Chen Y. Neural Regen Res. 2013 ...
PubMed ID: 25322856, Yan Y, Liang B, Zhang J, Liu Y, Bu X. Mol Med Rep. 2015 Jan;11(1):317-26. Doi: 1...
PubMed ID: 25703009, Li X, Wang L, Wang Z. Phys Med. 2015 Jun;31(4):352-9. Doi: 10.1016/J.Ejmp.2015.0...
PubMed ID: 25146667, Wei T, Tian W, Yan H, Shao G, Xie G. Cell Mol Neurobiol. 2014 Nov;34(8):1165-73....
PubMed ID: 25596671, Ding H, Wang H, Zhao Y, Sun D, Zhai X. Cell Mol Neurobiol. 2015 Jul;35(5):623-32...

*Showing only the more recent 20. More publications can be found for each product on its corresponding product page