Anti-CK19 KRT19 Monoclonal Antibody

Product Name

Anti-CK19 KRT19 Monoclonal Antibody

View all Cytokeratin 19 Antibodies

SKU/Catalog Number

M02101

Size

100ul

Form

Liquid

Description

Boster Bio Anti-CK19 KRT19 Monoclonal Antibody catalog # M02101. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-CK19 KRT19 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M02101)

Host

Mouse

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Monoclonal

Clone Number

11F5

Isotype

IgG

Immunogen

Synthetic Peptide

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M02101 is reactive to KRT19 in Human, Mouse, Rat

Applications

M02101 is guaranteed for IHC Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

44.106kDa

Background of Cytokeratin 19

Indoleamine 2, 3-dioxygenase1 (IDO1) is a 41-42 kD intracellular enzyme that catabolizes tryptophan into kynurenine. IDO1 modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO1 effects on immune suppression are due to decreased tryptophan availability and the generation of tryptophan metabolites, resulting in negative effects on T lymphocytes, including proliferation, function and survival. IDO1 may be involved in the suppression of the immune response to tumors, and blocking the IDO1 pathway may be a potential target for immuno and cancer therapy. IDO1 is expressed in a wide variety of tissues and can be upregulated by interferon gamma and other inflammatory cytokines.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

IHC 1:200

Validation Images & Assay Conditions

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Figure 1. Immunohistochemistry validation of KRT19 using Anti-CK19 KRT19 Monoclonal Antibody (M02101).

Immunohistochemistry (IHC) staining of Human Colon cancer tissue

Gene/Protein Information For KRT19 (Source: Uniprot.org, NCBI)

Alternative Names

40-kDa keratin intermediate filament; CK19; CK-19; Cytokeratin 19; EndoC; K19; K1CS; keratin 19; keratin, type I cytoskeletal 19; keratin, type I, 40-kd; keratin-19; Krt19; MGC15366 KRT19 CK19, K19, K1CS keratin 19 keratin, type I cytoskeletal 19|40-kDa keratin intermediate filament|CK-19|cytokeratin 19|keratin 19, type I|keratin, type I, 40-kd

For more info on KRT19, check out the KRT19 Infographic

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In this infographic, you will see the following information for KRT19: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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