Anti-Cleaved-Factor XII HC (R372) F12 Antibody

Product Name

Anti-Cleaved-Factor XII HC (R372) F12 Antibody

View all Factor XII heavy chain Antibodies

SKU/Catalog Number

A01226

Size

100μl

Form

Liquid

Description

Boster Bio Anti-Cleaved-Factor XII HC (R372) F12 Antibody catalog # A01226. Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Cleaved-Factor XII HC (R372) F12 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01226)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

2D3

Isotype

IgG

Immunogen

Synthesized peptide derived from the Internal region of human Factor XII HC. at AA rangle: 300-380

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A01226 is reactive to F12 in Human

Applications

A01226 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

67.792kDa

Background of Factor XII heavy chain

E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene. Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:500-1:2000

Validation Images & Assay Conditions

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Western Blot (WB) analysis of specific cells using Cleaved-Factor XII HC (R372) Polyclonal antibody.

Gene/Protein Information For F12 (Source: Uniprot.org, NCBI)

Alternative Names

beta-factor XIIa part 1; coagulation factor XII (Hageman factor); coagulation factor XII; coagulation factor XIIa heavy chain; coagulation factor XIIa light chain; EC 3.4.21; EC 3.4.21.38; HAE3; HAEX; HAFbeta-factor XIIa part 2; Hageman factor F12 HAE3, HAEX, HAF coagulation factor XII coagulation factor XII|Hageman factor|beta-factor XIIa part 1|beta-factor XIIa part 2|coagulation factor XIIa heavy chain|coagulation factor XIIa light chain

For more info on F12, check out the F12 Infographic

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In this infographic, you will see the following information for F12: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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