Anti-CSEN/KCNIP3 Antibody

Product Name

Anti-CSEN/KCNIP3 Antibody

View all Calsenilin Antibodies

SKU/Catalog Number

PA2272

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-CSEN/KCNIP3 Antibody catalog # PA2272. Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-CSEN/KCNIP3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA2272)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human CSEN.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA2272 is reactive to KCNIP3 in Human

Applications

PA2272 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

29 kDa

Calculated molecular weight

29.231kDa

Background of Calsenilin

KCNIP3, also known as Calsenilin, is a calcium-dependent transcriptional repressor that is highly expressed in central nervous system, thyroid gland, testis, thymus, and immune cells. This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins. KCNIP3 is mapped to 2q11.1. The encoded protein functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. KCNIP3-regulated genes have a critical function in Ig subclass production and proliferation in B lymphocytes. KCNIP3 has been shown to interact with PSEN1 and PSEN2.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human

Validation Images & Assay Conditions

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Anti-CSEN antibody, PA2272, Western blotting
All lanes: Anti CSEN (PA2272) at 0.5ug/ml
Lane 1: HELA Whole Cell Lysate at 40ug
Lane 2: U87 Whole Cell Lysate at 40ug
Lane 3: SHG Whole Cell Lysate at 40ug
Predicted bind size: 29KD
Observed bind size: 29KD

Gene/Protein Information For KCNIP3 (Source: Uniprot.org, NCBI)

Alternative Names

calsenilin; calsenilin, presenilin-binding protein, EF hand transcription factor; CSEN MGC18289; DREAM; DREAMA-type potassium channel modulatory protein 3; KCHIP3 DRE-antagonist modulator; KChIP3; Kv channel interacting protein 3, calsenilin; Kv channel-interacting protein 3; potassium channel interacting protein 3 KCNIP3 CSEN, DREAM, KCHIP3 potassium voltage-gated channel interacting protein 3 calsenilin|A-type potassium channel modulatory protein 3|DRE-antagonist modulator|Kv channel interacting protein 3, calsenilin|calsenilin, presenilin-binding protein, EF hand transcription factor|kv channel-interacting protein 3|potassium channel interacting protein 3

For more info on KCNIP3, check out the KCNIP3 Infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for KCNIP3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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