Anti-Ctip2 BCL11B Antibody

Product Name

Anti-Ctip2 BCL11B Antibody

View all Bcl11b Antibodies

SKU/Catalog Number

A01485

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Ctip2 BCL11B Antibody catalog # A01485. Tested in WB,IHC,IF,ICC,ELISA applications. This antibody reacts with Mouse.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Ctip2 BCL11B Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01485)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human FEN1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A01485 is reactive to Bcl11b in Mouse

Applications

A01485 is guaranteed for ELISA, IF, IHC, ICC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

94.566kDa

Background of Bcl11b

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

Murray J.M., Mol. Cell. Biol. 14:4878-4888(1994).
Hiraoka L.R., Genomics 25:220-225(1995).
Taylor T.D., Nature 440:497-500(2006).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:500-1:2000
IHC: 1:100-1:500
IF: 1:100-1:500
ICC: 1:100-1:500
ELISA: 1:5000-1:10000

Validation Images & Assay Conditions

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Figure 2. Immunocytochemistry staining of BCL11B using Anti-Ctip2 BCL11B Antibody (A01485).

ICC staining Ctip2 in LO2 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde

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Figure 1. Western blotting validation for Anti-Ctip2 BCL11B Antibody A01485

Western blot analysis of Ctip2 on THP-1 cells lysates using anti-Ctip2 antibody at 1/1

Gene/Protein Information For Bcl11b (Source: Uniprot.org, NCBI)

Alternative Names

B-cell CLL/lymphoma 11B (zinc finger protein); B-cell CLL/lymphoma 11B; B-cell CLL/lymphoma 11B/T-cell receptor delta constant region fusion protein; B-cell lymphoma/leukaemia 11B; B-cell lymphoma/leukemia 11B; BCL-11B; BCL11B/TRDC fusion; COUP-TF-interacting protein 2; CTIP-2; CTIP2ZNF856B; hRit1; hRIT1-alpha; Radiation-induced tumor suppressor gene 1 protein; RIT1; zinc finger protein hRit1 alpha Bcl11b|9130430L19Rik, AI604821, B630002E05Rik, BCL-11B, CTI, Ctip2, Ri, Rit1|B cell leukemia/lymphoma 11B|B-cell lymphoma/leukemia 11B|B-cell CLL/lymphoma 11B|B-cell lymphoma/leukaemia 11B|COUP-TF-interacting protein 2|mRit1|radiation-induced tumor suppressor gene 1 protein

For more info on Bcl11b, check out the Bcl11b Infographic

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In this infographic, you will see the following information for Bcl11b: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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