Anti-CUEDC2 Antibody

Product Name

Anti-CUEDC2 Antibody

View all CUEDC2 Antibodies

SKU/Catalog Number

A08885

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-CUEDC2 Antibody (Catalog # A08885). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

CUEDC2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-CUEDC2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08885)

Host

Rabbit

Contents

CUEDC2 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

CUEDC2 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human CUEDC2. The immunogen is located within the last 50 amino acids of CUEDC2.

Cross-reactivity

CUEDC2 antibody will not cross-react with CUEDC1.

Reactive Species

A08885 is reactive to CUEDC2 in Human, Mouse, Rat

Observed Molecular Weight

68 kDa

Calculated molecular weight

32.0 kDa

Background of CUEDC2

The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, ~40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation. CUE domains are present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found. CUEDC2 (CUE domain-containing protein 2) was found through a yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 also decreases the sumoylation of PR. CUEDC2 has also been found to interact with IKK-alpha and IKK-beta and decrease the activation of NF-κB by decreasing the activation of IKK.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A08885 is guaranteed for ELISA, ICC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

CUEDC2 antibody can be used for detection of CUEDC2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information CUEDC2

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