Anti-CYP2C19/Cytochrome P450 2C19 Antibody

CYP2C19 antibody

Boster Bio Anti-CYP2C19/Cytochrome P450 2C19 Antibody catalog # A02102. Tested in WB applications. This antibody reacts with Human.

Product Info Summary

SKU: A02102
Size: 100μl
Reactive Species: Human
Host: Rabbit
Application: WB

Product Name

Anti-CYP2C19/Cytochrome P450 2C19 Antibody

View all CYP2C19 Antibodies

SKU/Catalog Number

A02102

Size

100μl

Form

Liquid

Description

Boster Bio Anti-CYP2C19/Cytochrome P450 2C19 Antibody catalog # A02102. Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-CYP2C19/Cytochrome P450 2C19 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02102)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

9D7

Isotype

IgG

Immunogen

Synthesized peptide derived from the Internal region of human CYP2C19. at AA rangle: 210-290

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A02102 is reactive to CYP2C19 in Human

Applications

A02102 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

55.931kDa

Background of CYP2C19

MEK6 is a member of MAPKK protein kinase family. By using degenerate oligonucleotide primers from the conserved kinase domains of MKK3 and MKK4 two human cDNAs and 1 murine cDNA encoding closely related proteins of the MKK family were cloned. The two human clones appear to be different isoforms of the same gene generated by differential splicing: the shorter clone was designated MKK6, encodes a 278-amino acid protein, while the longer clone, designated MKK6b, encodes a 334-amino acid protein. MKK6 is about 80% identical to MKK3 and 40% identical to MKK4. 1.7-kb human MKK6 transcript is highly expressed in skeletal muscle, while an MKK6b-specific probe detected mRNA bands of 1.8, 2.4, and 4.5 kb that are enriched in heart, skeletal muscle, pancreas and liver. MKK6 plays an important role in intracellular signaling pathways leading toward activation of the p38 MAP kinase . MEK6 phosphorylates and activates p38 in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAPK mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.

Wang W, et al. (2002) Mol Cell Biol ; 22(10): 3389-403.
Raingeaud J, et al. (1996) Mol Cell Biol; 16(3): 1247-55.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:500-1:2000

Validation Images & Assay Conditions

Gene/Protein Information For CYP2C19 (Source: Uniprot.org, NCBI)

Gene Name

CYP2C19

Full Name

Cytochrome P450 2C19

Weight

55.931kDa

Superfamily

cytochrome P450 family

Alternative Names

Cytochrome P450 2C19 CYP2C19 CPCJ, CYP2C, CYPIIC17, CYPIIC19, P450C2C, P450IIC19 cytochrome P450 family 2 subfamily C member 19 cytochrome P450 2C19|(R)-limonene 6-monooxygenase|(S)-limonene 6-monooxygenase|(S)-limonene 7-monooxygenase|S-mephenytoin 4-hydroxylase|cytochrome P-450 II C|cytochrome P450, family 2, subfamily C, polypeptide 19|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19|cytochrome P450-11A|cytochrome P450-254C|fenbendazole monooxygenase (4-hydroxylating)|flavoprotein-linked monooxygenase|mephenytoin 4-hydroxylase|mephenytoin 4-hydroxylase|microsomal monooxygenase|xenobiotic monooxygenase

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on CYP2C19, check out the CYP2C19 Infographic

CYP2C19 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CYP2C19: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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6 Customer Q&As for Anti-CYP2C19/Cytochrome P450 2C19 Antibody

Question

Is this A02102 anti-CYP2C19/Cytochrome P450 2C19 antibody reactive to the isotypes of CYP2C19?

Verified Customer

Verified customer

Asked: 2020-01-21

Answer

The immunogen of A02102 anti-CYP2C19/Cytochrome P450 2C19 antibody is Synthesized peptide derived from the Internal region of human CYP2C19. at AA rangle: 210-290. Could you tell me which isotype you are interested in so I can help see if the immunogen is part of this isotype?

Boster Scientific Support

Answered: 2020-01-21

Question

Is a blocking peptide available for product anti-CYP2C19/Cytochrome P450 2C19 antibody (A02102)?

Verified Customer

Verified customer

Asked: 2019-06-26

Answer

We do provide the blocking peptide for product anti-CYP2C19/Cytochrome P450 2C19 antibody (A02102). If you would like to place an order for it please contact [email protected] and make a special request.

Boster Scientific Support

Answered: 2019-06-26

Question

Does anti-CYP2C19/Cytochrome P450 2C19 antibody A02102 work for WB with right lobe of liver?

Verified Customer

Verified customer

Asked: 2019-01-15

Answer

According to the expression profile of right lobe of liver, CYP2C19 is highly expressed in right lobe of liver. So, it is likely that anti-CYP2C19/Cytochrome P450 2C19 antibody A02102 will work for WB with right lobe of liver.

Boster Scientific Support

Answered: 2019-01-15

Question

Would anti-CYP2C19/Cytochrome P450 2C19 antibody A02102 work on horse WB with right lobe of liver?

J. Krishna

Verified customer

Asked: 2015-11-04

Answer

Our lab technicians have not validated anti-CYP2C19/Cytochrome P450 2C19 antibody A02102 on horse. You can run a BLAST between horse and the immunogen sequence of anti-CYP2C19/Cytochrome P450 2C19 antibody A02102 to see if they may cross-react. If the sequence homology is close, then you can perform a pilot test. Keep in mind that since we have not validated horse samples, this use of the antibody is not covered by our guarantee. However we have an innovator award program that if you test this antibody and show it works in horse right lobe of liver in WB, you can get your next antibody for free.

Boster Scientific Support

Answered: 2015-11-04

Question

I am interested in to test anti-CYP2C19/Cytochrome P450 2C19 antibody A02102 on human right lobe of liver for research purposes, then I may be interested in using anti-CYP2C19/Cytochrome P450 2C19 antibody A02102 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?

R. Rodriguez

Verified customer

Asked: 2015-05-12

Answer

The products we sell, including anti-CYP2C19/Cytochrome P450 2C19 antibody A02102, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.

Boster Scientific Support

Answered: 2015-05-12

Question

Does A02102 anti-CYP2C19/Cytochrome P450 2C19 antibody work on parafin embedded sections? If so, which fixation method do you recommend we use (PFA, paraformaldehyde, other)?

A. Mangal

Verified customer

Asked: 2013-06-03

Answer

As indicated on the product datasheet, A02102 anti-CYP2C19/Cytochrome P450 2C19 antibody as been tested on WB. It is best to use PFA for fixation because it has better tissue penetration ability. PFA needs to be prepared fresh before use. Long term stored PFA turns into formalin, as the PFA molecules congregate and become formalin.

Boster Scientific Support

Answered: 2013-06-03

Order DetailsPrice
A02102

100uL

$399

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