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- Table of Contents
Facts about Cytochrome P450 2C19.
Human | |
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Gene Name: | CYP2C19 |
Uniprot: | P33261 |
Entrez: | 1557 |
Belongs to: |
---|
cytochrome P450 family |
Cytochrome P450 2C19
Mass (kDA):
55.931 kDA
Human | |
---|---|
Location: | 10q23.33 |
Sequence: | 10; NC_000010.11 (94762681..94855547) |
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
What Are the Best Uses Of The CYP2 C19 Marker? Here are some of the reasons why scientists should use this marker. Listed below are some of the benefits of this marker. It can be used to test for the genotype of a specific person, species, or application. It is applicable to all scientists around the world. It can also be used to help scientists develop new compounds or improve existing ones.
Boster Bio CYP2C19 genetic tests are a reliable and affordable way to identify patients with rare blood disorders. This test is available for most common CYP2C19 polymorphisms, including CYP2C19*2 allele. There are no side effects associated with Boster Bio CYP2C19 genotype testing. Patients can use this test to help decide if they should undergo further tests to confirm their results.
The procedure for detecting CYP2E1 is based on indirect ELISA. The total sample protein is coated onto 96-well plates overnight. The protein is blocked with 5% nonfat milk. The protein is then incubated with purified anti-CYP2E1 IgY antibody and CYP2E1 IgG antibody for two hours at 37degC. Finally, the membranes are washed with TBST three times to remove unbound antibodies.
The CYP2C19 polymorphism has been associated with decreased antiplatelet response to clopidogrel. Studies have shown that CYP2C19 polymorphisms affect approximately 12-13% of the Caucasian population. Additionally, patients with CYP2C19*2 allele are at an increased risk for thrombotic events. Because of this, genetic testing for CYP2C19 is useful for patients with rare or inherited diseases.
Boster Bio CYP2C19 gene sequencing kits offer a broad range of genetic information. The company's highly sensitive ELISA kits are based on Picokine(tm) technology, which improves sensitivity to the picogram level. The company's ELISA kits are validated for a range of samples. The company's research is well-cited in over 29,000 publications and is highly reliable. Unlike other ELISA kits, Boster Bio antibodies are tested against untransfected cell lines to ensure their compatibility with different strains of bacteria.
Another method is known as IMB. It combines magnetic separation with visual readout. The IMBs have a distinct color change depending on their concentration and degree of aggregation. This color change enables readers to distinguish between concentrations of CYP2E1 from a few micrograms to one mg/mL. This technique is also suitable for large-scale screening and is portable.
Antibodies are readily available for CYP2C19. Boster Bio's anti-Cytochrome p450 2C19 antibody reacts to Human and Monkey CYP2C19. Using this antibody, you can determine the phenotype of your patient with a single test. It has a high affinity and can be used by scientists around the world.
CYP2E1 enzyme is one of the most important enzymes in metabolism. This enzyme catalyzes the metabolism of various xenobiotics and low-molecular-weight compounds. Alcohol, drugs, and acetaminophen increase the activity of CYP2E1 enzyme. Alcohol overdose also induces CYP2E1 expression, leading to higher levels of ROS and hydroxyl radicals. Increased oxidative stress can damage mitochondrial components.
This enzyme is a member of the cytochrome P450 superfamily. When analyzing its activity, Boster Bio CYP2C19 genotype testing can reveal which genes are mutated or missing. The results of these tests can be used to make decisions about potential therapeutics and pharmaceutical products. The Boster Bio CYP2C19 genotype test can be used for targeted drug development, cancer research, and personalized medicine.
CYP2C19 is a gene for the cytochrome P450 enzyme CYP. This marker can be used for many biological applications. Boster provides high-affinity primary antibodies for use in ELISA, immunohistochemistry, and Western blotting. The cost of blocking peptides varies according to length, and the antibody is validated for use in these applications.
PMID: 2009263 by Romkes M., et al. Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.
PMID: 8215410 by Wrighton S.A., et al. Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'-hydroxylation.