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Product Info Summary
| SKU: | A10889 |
|---|---|
| Size: | 100ul |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | IF, ICC, WB |
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Product info
Product Name
Anti-Cytohesin-1 CYTH1 Antibody
View all Cytohesin-1 Antibodies
SKU/Catalog Number
A10889
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Cytohesin-1 CYTH1 Antibody catalog # A10889. Tested in WB,ICC/IF applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Cytohesin-1 CYTH1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10889)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human PP4R2
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A10889 is reactive to CYTH1 in Human, Mouse, Rat
Applications
A10889 is guaranteed for IF, ICC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
46.413kDa
Background of Cytohesin-1
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.
Hastie C.J., Biochem. J. 347:845-855(2000).
Zhang W., Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
Mural R.J., Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:200-1:2000
ICC/IF: 1:50-1:200
Validation Images & Assay Conditions
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Figure 1. Western blotting validation for Anti-Cytohesin-1 CYTH1 Antibody A10889
Western blot analysis of extracts of various cell linesProtein Target Info & Infographic
Gene/Protein Information For CYTH1 (Source: Uniprot.org, NCBI)
Gene Name
CYTH1
Full Name
Cytohesin-1
Weight
46.413kDa
Alternative Names
B2-1; CYTH1; cytoadhesin 1; cytohesin 1; Cytohesin1; Cytohesin-1; D17S811ECYTOHESIN-1; FLJ34050; FLJ41900; homolog of secretory protein SEC7; PH, SEC7 and coiled-coil domain-containing protein 1; pleckstrin homology, Sec7 and coiled-coil domains 1; PSCD1; SEC7 homolog B2-1; SEC7 CYTH1 B2-1, CYTOHESIN-1, D17S811E, PSCD1, SEC7 cytohesin 1 cytohesin-1|PH, SEC7 and coiled-coil domain-containing protein 1|SEC7 homolog B2-1|cytoadhesin 1|homolog of secretory protein SEC7|pleckstrin homology, Sec7 and coiled-coil domains 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CYTH1, check out the CYTH1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CYTH1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Cytohesin-1 CYTH1 Antibody (A10889)
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No publications found for A10889
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