Anti-DcR3 TNFRSF6B Antibody

Product Name

Anti-DcR3 TNFRSF6B Antibody

View all TNFRSF6B Antibodies

SKU/Catalog Number

A04048-1

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-DcR3 TNFRSF6B Antibody (Catalog # A04048-1). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

DcR3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-DcR3 TNFRSF6B Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04048-1)

Host

Rabbit

Contents

DcR3 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

DcR3 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human DcR3 precursor. The immunogen is located within the first 50 amino acids of DcR3.

Reactive Species

A04048-1 is reactive to TNFRSF6B in Human, Mouse, Rat

Observed Molecular Weight

68 kDa

Calculated molecular weight

32.7 kDa

Background of TNFRSF6B

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively,. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis. DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A04048-1 is guaranteed for ELISA, IHC-P, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

DcR3 antibody can be used for detection of DcR3 expression by Western blot 0.5 μg/mL. An approximately 33 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 1 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information TNFRSF6B

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