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Product Info Summary
| SKU: | A08778 |
|---|---|
| Size: | 100ul |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | WB |
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Product info
Product Name
Anti-DNA polymerase delta subunit 4 POLD4 Antibody
SKU/Catalog Number
A08778
Size
100ul
Form
Liquid
Description
Boster Bio Anti-DNA polymerase delta subunit 4 POLD4 Antibody catalog # A08778. Tested in WB applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-DNA polymerase delta subunit 4 POLD4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08778)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human DEF-3
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A08778 is reactive to POLD4 in Human
Applications
A08778 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
12.433kDa
Background of POLD4
A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner By similarity. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.
Ota T., Nat. Genet. 36:40-45(2004).
Ebert L., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Boulon S., Mol. Cell 16:777-787(2004).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:2000
Validation Images & Assay Conditions
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Figure 1. Western blotting validation for Anti-DNA polymerase delta subunit 4 POLD4 Antibody A08778
Western blot analysis of extracts of MCF7 cellsProtein Target Info & Infographic
Gene/Protein Information For POLD4 (Source: Uniprot.org, NCBI)
Gene Name
POLD4
Full Name
DNA polymerase delta subunit 4
Weight
12.433kDa
Superfamily
DNA polymerase delta subunit 4 family
Alternative Names
DNA polymerase delta smallest subunit p12; DNA polymerase delta subunit p12; p12; POLDSDNA polymerase delta subunit 4; polymerase (DNA-directed), delta 4 POLD4 POLDS, p12 DNA polymerase delta 4, accessory subunit DNA polymerase delta subunit 4|DNA polymerase delta smallest subunit p12|polymerase (DNA) delta 4, accessory subunit|polymerase (DNA-directed), delta 4, accessory subunit
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on POLD4, check out the POLD4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for POLD4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-DNA polymerase delta subunit 4 POLD4 Antibody (A08778)
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No publications found for A08778
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