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Product Info Summary
| SKU: | A02896 |
|---|---|
| Size: | 100ul |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | IHC |
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Product info
Product Name
Anti-E2F-2 (K236) Antibody
SKU/Catalog Number
A02896
Size
100ul
Form
Liquid
Description
Boster Bio Anti-E2F-2 (K236) Antibody catalog # A02896. Tested in IHC applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-E2F-2 (K236) Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02896)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
Synthetic peptide, corresponding to amino acids 202-252 of Human E2F-2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A02896 is reactive to E2F2 in Human, Mouse, Rat
Applications
A02896 is guaranteed for IHC Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
47.506kDa
Background of E2F-2
Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.
Kajita Y., J. Biol. Chem. 270:22167-22175(1995).
Dempsey L.A., Genomics 49:378-384(1998).
Tolnay M., Biochem. J. 338:417-425(1999).
Grosset C., Cell 103:29-40(2000)
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Innovating Scientists Reward
If you are the first to review this product, or if you have results for a special sample, species or application this product is not validated in, share your results with us and receive product credits you can use towards any Boster products! Applicable to all scientists worldwide.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IHC: 1:50-1:200
Validation Images & Assay Conditions
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Figure 1. Immunohistochemistry validation of E2F2 using Anti-E2F-2 (K236) Antibody (A02896).
Immunohistochemistry (IHC) analyzes of E2F-2 (K236) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.For more protocol information of IHC
Protein Target Info & Infographic
Gene/Protein Information For E2F2 (Source: Uniprot.org, NCBI)
Gene Name
E2F2
Full Name
Transcription factor E2F2
Weight
47.506kDa
Superfamily
E2F/DP family
Alternative Names
E2F transcription factor 2; E2F2; E2F-2; E2F-2transcription factor E2F2 E2F2 E2F-2 E2F transcription factor 2 transcription factor E2F2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on E2F2, check out the E2F2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for E2F2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-E2F-2 (K236) Antibody (A02896)
Hello CJ!
A02896 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
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