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Product Info Summary
| SKU: | A11139 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-EFCAB4B CRACR2A Antibody
SKU/Catalog Number
A11139
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-EFCAB4B CRACR2A Antibody (Catalog # A11139). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
EFCAB4B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-EFCAB4B CRACR2A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A11139)
Host
Rabbit
Contents
EFCAB4B Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
Clone: SK7
Isotype
IgG
Immunogen
EFCAB4B antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human EFCAB4B. The immunogen is located within amino acids 640 - 690 of EFCAB4B.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This antibody is predicted to have no cross-reactivity to ZBED2 or ZBED3.
Reactive Species
A11139 is reactive to CRACR2A in Human, Mouse
Applications
A11139 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
45.592kDa
Background of EFCAB4B
EFCAB4B, also known as Calcium release-activated calcium channel regulator 2A, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation. EFCAB4B acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration. A closely related protein, EFCAB4A, is likely to play a similar role as EFCAB4B, but the detailed function of EFCAB4A is still under investigation.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
EFCAB4B antibody can be used for detection of EFCAB4B by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of EFCAB4B in mouse kidney tissue lysate with EFCAB4B antibody at 1 μg/mL.
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Immunohistochemistry of EFCAB4B in human kidney tissue with EFCAB4B antibody at 10 μg/mL.
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Immunofluorescence of EFCAB4B in human kidney tissue with EFCAB4B antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For CRACR2A (Source: Uniprot.org, NCBI)
Gene Name
CRACR2A
Full Name
EF-hand calcium-binding domain-containing protein 4B
Weight
45.592kDa
Superfamily
EFCAB4 family
Alternative Names
Calcium release-activated calcium channel regulator 2A; CRAC channel regulator 2A; CRACR2A; DKFZp686G13246; EF-hand calcium binding domain 4B; EF-hand calcium-binding domain-containing protein 4B; FLJ33046; FLJ33805; MGC4266 CRACR2A EFCAB4B calcium release activated channel regulator 2A EF-hand calcium-binding domain-containing protein 4B|CRAC channel regulator 2A|CRAC regulator 2A|Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A|EF-hand calcium binding domain 4B|calcium release-activated calcium channel regulator 2A
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CRACR2A, check out the CRACR2A Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CRACR2A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-EFCAB4B CRACR2A Antibody (A11139)
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No publications found for A11139
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