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Product Info Summary
| SKU: | A07322 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-EVER1 TMC6 Antibody
SKU/Catalog Number
A07322
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-EVER1 TMC6 Antibody (Catalog # A07322). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
EVER1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-EVER1 TMC6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07322)
Host
Rabbit
Contents
EVER1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
EVER1 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human EVER1. The immunogen is located within the first 50 amino acids of EVER1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.
Reactive Species
A07322 is reactive to TMC6 in Human, Mouse, Rat
Applications
A07322 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
90.045kDa
Background of TMC6
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
EVER1 antibody can be used for the detection of EVER1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of EVER1 in A-20 cell lysate with EVER1 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of EVER1 in human spleen with EVER1 antibody at 2.5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TMC6 (Source: Uniprot.org, NCBI)
Gene Name
TMC6
Full Name
Transmembrane channel-like protein 6
Weight
90.045kDa
Superfamily
TMC family
Alternative Names
epidermodysplasia verruciformis 1; Epidermodysplasia verruciformis protein 1; EVER1FLJ17776; EVIN1EV1; expressed in activated T/LAK lymphocytes; LAK-4P; Protein LAK-4; transmembrane channel-like 6; transmembrane channel-like protein 6 TMC6 EV1, EVER1, EVIN1, LAK-4P, TNRC6C-AS1, lnc transmembrane channel like 6 transmembrane channel-like protein 6|TNRC6C antisense RNA 1|epidermodysplasia verruciformis 1|epidermodysplasia verruciformis protein 1|expressed in activated T/LAK lymphocytes|protein LAK-4
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TMC6, check out the TMC6 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TMC6: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-EVER1 TMC6 Antibody (A07322)
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No publications found for A07322
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