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Product Info Summary
| SKU: | M00011-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Mouse |
| Application: | Flow Cytometry, WB |
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Product info
Product Name
Anti-FoxP3 Purified Monoclonal Antibody
SKU/Catalog Number
M00011-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-FoxP3 Purified Monoclonal Antibody (Catalog# M00011-1). Tested in Flow Cytometry, WB application(s). This antibody reacts with Human, Mouse.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-FoxP3 Purified Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00011-1)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
3G3
Isotype
Mouse IgG1 kappa
Immunogen
Full-length His-tagged recombinant murine FoxP3. The mouse monoclonal antibody 3G3 recognizes N-terminal region of FoxP3, a 47-55 kDa transcription factor (intracellular antigen), which is the master regulator in the development and function of regulatory T cells.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
M00011-1 is reactive to Foxp3 in Human, Mouse
Applications
M00011-1 is guaranteed for Flow Cytometry, WB Boster Guarantee
Observed Molecular Weight
42 kDa
Calculated molecular weight
47.346kDa
Background of Foxp3
FoxP3 (forkhead box protein 3), a highly conserved forkhead/winged-helix transcription factor, plays a crucial role in maintaining immune homeostasis by governing the development and function of regulatory T cells. It is constitutively expressed at high level in CD25+ CD4+ Treg cells and at low level in a CD25- CD4+ Treg cell subset. Defects in gene encoding FoxP3 protein cause the scurfy phenotype in mice, and in human the IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blotting: 2 μg/ml.
Flow cytometry: 1-4 µg/ml. Intracellular staining.
Validation Images & Assay Conditions
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Protein Target Info & Infographic
Gene/Protein Information For Foxp3 (Source: Uniprot.org, NCBI)
Gene Name
Foxp3
Full Name
Forkhead box protein P3
Weight
47.346kDa
Alternative Names
AIID; AIIDMGC141961; human foxp3; mouse foxp3; DIETER; forkhead box P3; Forkhead Box Protein P3; foxp3 ihc; foxp3 paraffin; FoxP3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-Linked; IPEX; JM2; MGC141961; MGC141963; PIDX; PIDXMGC141963; SCURFIN; XPID; XPIDpolyendocrinopathy, enteropathy, X-linked Foxp3|JM2, scu, scurfin, sf|forkhead box P3|forkhead box protein P3|scurfy
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Foxp3, check out the Foxp3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Foxp3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-FoxP3 Purified Monoclonal Antibody (M00011-1)
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No publications found for M00011-1
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Customer Reviews
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