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Product Info Summary
| SKU: | M03219 |
|---|---|
| Size: | 50 µl |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | WB |
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Product info
Product Name
Anti-FZR Antibody
SKU/Catalog Number
M03219
Size
50 µl
Description
Boster Bio Anti-FZR Antibody (Catalog # M03219). Tested in WB application(s). This antibody reacts with Human.
Storage & Handling
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Cite This Product
Anti-FZR Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M03219)
Host
Mouse
Contents
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Clonality
Monoclonal
Clone Number
1621CT637.76.67
Isotype
IgG1,k
Immunogen
This FZR antibody is generated from a mouse immunized with a recombinant protein between1-496 amino acids from human FZR.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
M03219 is reactive to FZR1 in Human
Applications
M03219 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
55.179kDa
Background of FZR1/CDH1
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:2000
Validation Images & Assay Conditions
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All lanes : Anti-FZR Antibody at 1:2000 dilution
Lane 1: 293T/17 whole cell lysate
Lane 2: Hela whole cell lysate
Lysates/proteins at 20 µg per lane.
Secondary
Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.
Predicted band size : 55 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.
Protein Target Info & Infographic
Gene/Protein Information For FZR1 (Source: Uniprot.org, NCBI)
Gene Name
FZR1
Full Name
Fizzy-related protein homolog
Weight
55.179kDa
Superfamily
WD repeat CDC20/Fizzy family
Alternative Names
CDC20C; CDH1; Cdh1/Hct1 homolog; CDH1CDC20-like 1b; fizzy/cell division cycle 20 related 1 (Drosophila); Fzr; FZR2; FZRCDC20-like protein 1; hCDH1; HCDHFYR; KIAA1242fizzy-related protein homolog FZR1 CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1 fizzy and cell division cycle 20 related 1 fizzy-related protein homolog|CDC20 homolog 1|CDC20-like 1b|CDC20-like protein 1|cdh1/Hct1 homolog|fizzy/cell division cycle 20 related 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on FZR1, check out the FZR1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for FZR1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-FZR Antibody (M03219)
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No publications found for M03219
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