Anti-Histone deacetylase 6 HDAC6 Antibody
Rabbit IgG polyclonal antibody for Histone deacetylase 6(HDAC6) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Anti-Histone deacetylase 6 HDAC6 Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
|Product Name||Anti-Histone deacetylase 6 HDAC6 Antibody
See all HDAC6 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for HISTONE DEACETYLASE 6/HDAC6 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. HISTONE DEACETYLASE 6/HDAC6 information: Molecular Weight: 131419 MW; Subcellular Localization: Nucleus. Cytoplasm. Perikaryon . Cell projection, dendrite . Cell projection, axon . It is mainly cytoplasmic, where it is associated with microtubules.|
|Cite This Product||Anti-Histone deacetylase 6 HDAC6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1601)|
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|Anti-Histone deacetylase 6 HDAC6 Antibody may replace the following items: sc 28386|sc 5255|sc 5258|sc 11420.|
|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human HDAC6(1195-1209aa LLDVKNIAHQNKFGE), different from the related rat and mouse sequences by two amino acids.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For HDAC6 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||10013|
|Species Of This Entry||Human|
|Protein Name||Histone deacetylase 6|
|Superfamily||histone deacetylase family|
|Alternative Names||HDAC6|EC 188.8.131.52; HD6FLJ16239; histone deacetylase 6; JM21; KIAA0901|
|Post Tranlational Modifications||Acetylation; Deacetylation; Phosphorylation; Ubiquitination; Cleavage; Dephosphorylation; Reduction; Farnesylation; Methylation; Carboxylation; Ribosylation; Biotinylation; Glycosylation|
|Subcellular Localization||Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Perikaryon. Cell projection, dendrite. Cell projection, axon. It is mainly cytoplasmic, where it is associated with microtubules.|
|Gene Location||Xp11.23, on Chromasome X, gene sequence: NC_000023.11 (48801398..48824982)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For HDAC6 (Source: Uniprot.org, NCBI)
|Protein Function||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.|
|Interacting Proteins||ATP13A2; BRMS1; Cdc20; CTNNB1; CTTN; Cttn; CYLD; EGFR; MYD88; PRKCA; PRKN; PROM1|
|Research Areas||Breast Cancer; Cancer; Cell Cycle and Replication; Chromatin Research|
|Related Diseases||Malignant Neoplasms; Neoplasms; Malignant Neoplasm Of Breast; Neurodegenerative Disorders; Mammary Neoplasms; Traditional Serrated Adenoma; Neoplasm Metastasis; Carcinoma; Leukemia; Cell Invasion; Nerve Degeneration; Cell Transformation, Neoplastic; Tumor Angiogenesis; Malignant Neoplasm Of Prostate; Tissue Adhesions; Myeloid Leukemia; Parkinson Disease; Multiple Myeloma; Leukemia, Myelocytic, Acute|
|Related Pathways||Cell Migration; Autophagy; Transport; Localization; Cell Motility; Cell Death; Cell Cycle; Cell Growth; Histone Acetylation; Cell Proliferation; Tubulin Deacetylation; Angiogenesis; Pathogenesis; Protein Acetylation; Cell Cycle Arrest; Translation; Rna Interference; Alpha-tubulin Acetylation; Mitosis; Nuclear Export|
|Background||HDAC6, also called KIAA0901, is a member belsongs to clas II of the histone deacetylase/acuc/apha family of proteins that is an enzyme that in humans is encoded by the HDAC6 gene. The HDAC6 gene is mapped to chromosome Xp11.23. HDAC6 contains an internal duplication of two catalytic domains which appear to function independently of each other. The protein possesses histone deacetylase activity and represses transcription. HDAC6 functions as a tubulin deacetylase. And it is localized exclusively in the cytoplasm, where it associates with microtubules and localizes with the microtubule motor complex. HDAC6 could bind both polyubiquitinated misfolded proteins and dynein motors, thereby recruiting misfolded protein cargo to dynein motors for transport to aggresomes. Furthermore, expression of HDAC6 was sufficient to rescue degeneration associated with UPS dysfunction in vivo in an autophagy-dependent manner. HDAC6 is a central component of the stress response that regulates SG formation and potentially contributes to control of RNA metabolism and translation.|
|Scientific References||PMID: 10220385 by Grozinger C.M., et al. Three proteins define a class of human histone deacetylases related to yeast Hda1p.|
PMID: 11533236 by Amann J.M., et al. ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.
Our Boster Quality Guarantee for Anti-Histone deacetylase 6 HDAC6 Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Rat, Human, Mouse, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: Rat Brain Tissue Lysate
Lane 2: Rat Testis Tissue Lysate
Lane 3: HELA Cell Lysate
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
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