Product Info Summary
SKU: | A09185 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | IHC, WB |
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Product info
Product Name
Anti-Helicase POLQ-like HELQ Antibody
View all DNA helicase HEL308 Antibodies
SKU/Catalog Number
A09185
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Helicase POLQ-like HELQ Antibody catalog # A09185. Tested in WB,IHC applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Helicase POLQ-like HELQ Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09185)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Recombinant protein of human HELQ
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A09185 is reactive to HELQ in Human, Mouse, Rat
Applications
A09185 is guaranteed for IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
124.131kDa
Background of DNA helicase HEL308
Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion By similarity.The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release By similarity.
Urade Y., Proc. Natl. Acad. Sci. U.S.A. 88:1069-1073(1991).
Ota T., Nat. Genet. 36:40-45(2004).
Mural R.J., Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:1000-1:3000
IHC: 1:50-1:200
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of extracts of various cell lines, using HELQ antibody at 1:3000 dilution.
Protein Target Info & Infographic
Gene/Protein Information For HELQ (Source: Uniprot.org, NCBI)
Gene Name
HELQ
Full Name
Helicase POLQ-like
Weight
124.131kDa
Superfamily
helicase family
Alternative Names
EC 3.6.1; EC 3.6.4.12; Hel308; HEL308DNA helicase HEL308; helicase POLQ-like; helicase, POLQ-like; MGC20604; Mus308-like helicase; POLQ-like helicase HELQ HEL308 helicase, POLQ like helicase POLQ-like|DNA helicase HEL308|POLQ-like helicase|mus308-like helicase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on HELQ, check out the HELQ Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for HELQ: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Helicase POLQ-like HELQ Antibody (A09185)
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No publications found for A09185
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Customer Reviews
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Customer Q&As
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1 Customer Q&As for Anti-Helicase POLQ-like HELQ Antibody
Question
Can A09185 recognize PolQ helicase domain?
Verified customer
Asked: 2020-11-10
Answer
It might not be able to recognize this domain, the Anti-Helicase POLQ-like HELQ Antibody (A09185) is Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human HEL308.
Boster Scientific Support
Answered: 2020-11-12