Anti-HMGCR Antibody Picoband™

HMG-CoA Reductase/HMGCR antibody

Boster Bio Anti-HMGCR Antibody Picoband™ catalog # A00643-3. Tested in ELISA, Flow Cytometry, IF, IHC, WB applications. This antibody reacts with Human.

Product Info Summary

SKU: A00643-3
Size: 100 μg/vial
Reactive Species: Human
Host: Rabbit
Application: ELISA, Flow Cytometry, IF, IHC, WB

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Product Name

Anti-HMGCR Antibody Picoband™

View all HMG-CoA Reductase/HMGCR Antibodies

SKU/Catalog Number

A00643-3

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-HMGCR Antibody Picoband™ catalog # A00643-3. Tested in ELISA, Flow Cytometry, IF, IHC, WB applications. This antibody reacts with Human.

Storage & Handling

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Cite This Product

Anti-HMGCR Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00643-3)

Host

Rabbit

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

E.coli-derived human HMGCR recombinant protein (Position: H268-V842).

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins.

Reactive Species

A00643-3 is reactive to HMGCR in Human

Applications

A00643-3 is guaranteed for ELISA, Flow Cytometry, IF, IHC, WB Boster Guarantee

Observed Molecular Weight

97 kDa

Calculated molecular weight

97.476kDa

Background of HMG-CoA Reductase/HMGCR

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.25-0.5 μg/ml, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human
Immunofluorescence, 5 μg/ml, Human
Flow Cytometry, 1-3 μg/1x106 cells, Human
Direct ELISA, 0.1-0.5 μg/ml, Human

Validation Images & Assay Conditions

Gene/Protein Information For HMGCR (Source: Uniprot.org, NCBI)

Gene Name

HMGCR

Full Name

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Weight

97.476kDa

Superfamily

HMG-CoA reductase family

Alternative Names

3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; EC 1.1.1; EC 1.1.1.34; HMG-CoA Reductase; HMGCR; Hydroxymethylglutaryl-CoA Reductase; LDLCQ3 HMGCR LDLCQ3 3-hydroxy-3-methylglutaryl-CoA reductase 3-hydroxy-3-methylglutaryl-Coenzyme A reductase|3-hydroxy-3-methylglutaryl CoA reductase (NADPH)|HMG-CoA reductase|hydroxymethylglutaryl-CoA reductase

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on HMGCR, check out the HMGCR Infographic

HMGCR infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for HMGCR: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A00643-3

100μg

$370
A00643-3-10ug

10μg sample (liquid)

$99
A00643-3-Biotin

100 μg Biotin conjugated

$570
A00643-3-Cy3

100 μg Cy3 conjugated

$570
A00643-3-Dylight488

100 μg Dylight488 conjugated

$570
A00643-3-Dylight550

100 μg Dylight550 conjugated

$570
A00643-3-Dylight594

100 μg Dylight594 conjugated

$570
A00643-3-FITC

100 μg FITC conjugated

$570
A00643-3-HRP

100 μg HRP conjugated

$570
A00643-3-APC

100 μg APC conjugated

$670
A00643-3-PE

100 μg PE conjugated

$670
A00643-3-carrier-free

Carrier Free

$370

More conjugates/formats

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A00643-3
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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