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- Table of Contents
HMGCR Antibodies
AND HMGCR ELISA kits, HMGCR Proteins
Many biological assays use antibodies to detect HMGCR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HMGCR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HMGCR antibodies...
Designing a Western blot for HMGCR? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the HMGCR Western Blot GuideDesigning an IHC experiment for HMGCR? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the HMGCR IHC GuideHMGCR Infographic by Boster Bio
All HMGCR Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A00643-3
100 μg/vial
Cat # A00643-3
100 μg/vial
Human, Mouse, Rat
IP, WB
$370
Cat # M00643
100 μl
Cat # M00643
100 μl
Fruit fly
IP, WB
$470
Cat # DZ41964
200 μl/vial
Cat # DZ41964
200 μl/vial
HMGCR Overview
Facts about 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)
Transmembrane glycoprotein that's the rate-limiting enzyme in cholesterol biosynthesis in addition to in the biosynthesis of nonsterol isoprenoids that are important for normal cell function such as ubiquinone and geranylgeranyl proteins. .
Gene Information
| Human | |
|---|---|
| Gene Name: | HMGCR |
| Uniprot: | P04035 |
| Entrez: | 3156 |
Family
| Belongs to: |
|---|
| HMG-CoA reductase family |
Alternative Names
3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; EC 1.1.1; EC 1.1.1.34; HMG-CoA Reductase; HMGCR; Hydroxymethylglutaryl-CoA Reductase; LDLCQ3
Molecular Weight
Mass (kDA):
97.476 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q13.3 |
| Sequence: | 5; NC_000005.10 (75336334..75362116) |
Subcellular Localizations
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Diseases
- Cardiovascular Diseases
- Malignant Neoplasms
- Atherosclerosis
- Hypercholesterolemia
- Neoplasms
- Alzheimer's Disease
- Diabetes Mellitus
- Heart Diseases
- Inflammation
- Coronary Heart Disease
- Fatty Liver
- Infarction
- Myocardial Infarction
Interacting Proteins
- UBIAD1
Pathways
- Cholesterol Homeostasis
- Transport
- Response To Statin
- Pathogenesis
- Secretion
- Prenylation
- Cell Migration
- Cell Proliferation
- Cell Growth
- Reverse Transcription
- Gluconeogenesis
- Myelination
- Cholesterol Efflux
PTMs
- Phosphorylation
- Prenylation
- Reduction
- Geranylgeranylation
- Cleavage
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HMGCR
bosterbio.com/bosterbio-gene-info-cards/HMGCR
References
PMID: 2991281 by Luskey K.L., et al. Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation.
PMID: 6995544 by Brown M.S., et al. Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.