Product Info Summary
SKU: | M06261-1 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse |
Host: | Mouse |
Application: | Flow Cytometry, IHC-F, WB |
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Product info
Product Name
Anti-Hu CD266 Purified TNFRSF12A Monoclonal Antibody
View all TWEAK R/TNFRSF12 Antibodies
SKU/Catalog Number
M06261-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Hu CD266 Purified TNFRSF12A Monoclonal Antibody (Catalog# M06261-1). Tested in Flow Cytometry, WB, IHC-F application(s). This antibody reacts with Mouse, Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-Hu CD266 Purified TNFRSF12A Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M06261-1)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
ITEM-4
Isotype
Mouse IgG2b
Immunogen
Human CD266-transfected P815 cells. The mouse monoclonal antibody ITEM-4 recognizes an extracellular epitope of CD266 / TWEAK R, a TNFR superfamily receptor for CD255 / TWEAK, a TNF-like weak inducer of apoptosis.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Cross-reactivity with CLIC5b was not determined.
Reactive Species
M06261-1 is reactive to Tnfrsf12a in Human, Mouse
Applications
M06261-1 is guaranteed for Flow Cytometry, IHC-F, WB Boster Guarantee
Observed Molecular Weight
42 kDa
Calculated molecular weight
13.641kDa
Background of TWEAK R/TNFRSF12
CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow cytometry: 1-4 µg/ml
Validation Images & Assay Conditions
There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.
Protein Target Info & Infographic
Gene/Protein Information For Tnfrsf12a (Source: Uniprot.org, NCBI)
Gene Name
Tnfrsf12a
Full Name
Tumor necrosis factor receptor superfamily member 12A
Weight
13.641kDa
Alternative Names
CD266 antigen; CD266; FGF-inducible 14; Fibroblast growth factor-inducible immediate-early response protein 14; Fn14; FN14tumor necrosis factor receptor superfamily member 12A; TNFRSF12; TNFRSF12A; tumor necrosis factor receptor superfamily, member 12A; TWEAK R; TWEAKR; tweak-receptor; type I transmembrane protein Fn14 Tnfrsf12a|AI255180, C87282, Fn1, Fn14, HPIP, TWEAK, TWEAK-R, Twea, TweakR|tumor necrosis factor receptor superfamily, member 12a|tumor necrosis factor receptor superfamily member 12A|FGF-inducible 14|fibroblast growth factor-inducible immediate-early response protein 14|fibroblast growth factor-regulated protein 2|tweak-receptor|type I transmembrane protein Fn14
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Tnfrsf12a, check out the Tnfrsf12a Infographic
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In this infographic, you will see the following information for Tnfrsf12a: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Hu CD266 Purified TNFRSF12A Monoclonal Antibody (M06261-1)
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No publications found for M06261-1
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