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Product Info Summary
| SKU: | M32176 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | Flow Cytometry, WB |
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Product info
Product Name
Anti-LARGE1 Purified Monoclonal Antibody
SKU/Catalog Number
M32176
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-LARGE1 Purified Monoclonal Antibody (Catalog# M32176). Tested in Flow Cytometry, WB application(s). This antibody reacts with Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-LARGE1 Purified Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M32176)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
LARGE-02
Isotype
Mouse IgG2b
Immunogen
Recombinant fragment of human LARGE1 (amino acids 35-142). The mouse monoclonal antibody LARGE-02 recognizes human LARGE1, a glycosyltransferase expressed mainly in the Golgi apparatus.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Cross-reactivity with LARGE2 was not determined.
Reactive Species
M32176 is reactive to LARGE1 in Human
Applications
M32176 is guaranteed for Flow Cytometry, WB Boster Guarantee
Observed Molecular Weight
42 kDa
Calculated molecular weight
88.066kDa
Background of LARGE1
LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow cytometry: 1-5 μg/ml. Intracellular staining.
Validation Images & Assay Conditions
There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.
Protein Target Info & Infographic
Gene/Protein Information For LARGE1 (Source: Uniprot.org, NCBI)
Gene Name
LARGE1
Full Name
LARGE xylosyl- and glucuronyltransferase 1
Weight
88.066kDa
Alternative Names
LARGE xylosyl- and glucuronyltransferase 1 LARGE1 LARGE, MDC1D, MDDGA6, MDDGB6 LARGE xylosyl- and glucuronyltransferase 1 LARGE xylosyl- and glucuronyltransferase 1|acetylglucosaminyltransferase-like 1A|acetylglucosaminyltransferase-like protein|glycosyltransferase-like protein LARGE1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on LARGE1, check out the LARGE1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for LARGE1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-LARGE1 Purified Monoclonal Antibody (M32176)
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No publications found for M32176
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