Anti-MRP4/ABCC4 Antibody Picoband™

MRP4/ABCC4 antibody

Boster Bio Anti-MRP4/ABCC4 Antibody Picoband™ catalog # A01596. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. Cited in 1 publication(s).

Product Info Summary

SKU: A01596
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: Flow Cytometry, IF, IHC, ICC, WB

Product Name

Anti-MRP4/ABCC4 Antibody Picoband™

View all MRP4/ABCC4 Antibodies

SKU/Catalog Number

A01596

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-MRP4/ABCC4 Antibody Picoband™ catalog # A01596. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-MRP4/ABCC4 Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01596)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

E.coli-derived human MRP4 recombinant protein (Position: M1-K77).

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins.

Reactive Species

A01596 is reactive to ABCC4 in Human, Mouse, Rat

Applications

A01596 is guaranteed for Flow Cytometry, IF, IHC, ICC, WB Boster Guarantee

Observed Molecular Weight

200-250 kDa

Calculated molecular weight

149.527kDa

Background of MRP4/ABCC4

ABCC4 (Atp-binding cassette, subfamily c, member 4), also known as MRP4 or MOATB, is a protein that in humans is encoded by the ABCC4 gene. It belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. This gene is mapped to chromosome 13q32. ABCC4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of ABCC4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of ABCC4 activity or knockdown of ABCC4 via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. It has been found that ABCC4 contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 2μg/ml, Human
Flow Cytometry, 1-3μg/1x106 cells, Human

Validation Images & Assay Conditions

Gene/Protein Information For ABCC4 (Source: Uniprot.org, NCBI)

Gene Name

ABCC4

Full Name

Multidrug resistance-associated protein 4

Weight

149.527kDa

Superfamily

ABC transporter superfamily

Alternative Names

ABCC4; ATP-binding cassette sub-family C member 4; ATP-binding cassette, sub-family C (CFTR/MRP), member 4; EST170205; MOATB; MOAT-BbA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4); MOATBcanalicular multispecific organic anion transporter (ABC superfamily); MRP4; MRP4MRP/cMOAT-related ABC transporter; multidrug resistance-associated protein 4; multispecific organic anion transporter B; Multi-specific organic anion transporter B ABCC4 MOAT-B, MOATB, MRP4 ATP binding cassette subfamily C member 4 multidrug resistance-associated protein 4|MRP/cMOAT-related ABC transporter|bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)|canalicular multispecific organic anion transporter (ABC superfamily)|multi-specific organic anion transporter B

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on ABCC4, check out the ABCC4 Infographic

ABCC4 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for ABCC4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

A01596 has been cited in 1 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Chen L,Liao L,Zhai T,Huang X,Chen Y.Influence of Orally Administered Borneol on the Expression of Hepatic Transporters in Rats.Eur J Drug Metab Pharmacokinet.2019 Feb;44(1):103-109.doi:10.1007/s13318-018-0499-1.PMID:30105488.
Species: Rat
A01596 usage in article: APP:WB, SAMPLE:LIVER TISSUE, DILUTION:NA

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5 Customer Q&As for Anti-MRP4/ABCC4 Antibody Picoband™

Question

I was wanting to use your anti-MRP4/ABCC4 antibody for WB for human leukemic t-cell on frozen tissues, but I want to know if it has been tested for this particular application. Has this antibody been tested and is this antibody a good choice for human leukemic t-cell identification?

Verified Customer

Verified customer

Asked: 2019-12-04

Answer

As indicated on the product datasheet, A01596 anti-MRP4/ABCC4 antibody has been tested for WB on human tissues. We have an innovator award program that if you test this antibody and show it works in human leukemic t-cell in IHC-frozen, you can get your next antibody for free.

Boster Scientific Support

Answered: 2019-12-04

Question

Is this A01596 anti-MRP4/ABCC4 antibody reactive to the isotypes of ABCC4?

Verified Customer

Verified customer

Asked: 2019-09-13

Answer

The immunogen of A01596 anti-MRP4/ABCC4 antibody is E.coli-derived human MRP4 recombinant protein (Position: M1-K77). Could you tell me which isotype you are interested in so I can help see if the immunogen is part of this isotype?

Boster Scientific Support

Answered: 2019-09-13

Question

My question regarding product A01596, anti-MRP4/ABCC4 antibody. I was wondering if it would be possible to conjugate this antibody with biotin. I would need it to be without BSA or sodium azide. I am planning on using a buffer exchange of sodium azide with PBS only. Would there be problems for me to conjugate the antibody and store it in -20 degrees in small aliquots?

E. Kulkarni

Verified customer

Asked: 2019-03-04

Answer

We suggest not storing this antibody with PBS buffer only in -20 degrees. If you want to store it in -20 degrees it is best to add some cryoprotectant like glycerol. If you want carrier free A01596 anti-MRP4/ABCC4 antibody, we can provide it to you in a special formula with trehalose and/or glycerol. These molecules will not interfere with conjugation chemistry and provide a good level of protection for the antibody from degradation. Please be sure to specify this in your purchase order.

Boster Scientific Support

Answered: 2019-03-04

Question

Is a blocking peptide available for product anti-MRP4/ABCC4 antibody (A01596)?

L. Evans

Verified customer

Asked: 2019-01-01

Answer

We do provide the blocking peptide for product anti-MRP4/ABCC4 antibody (A01596). If you would like to place an order for it please contact [email protected] and make a special request.

Boster Scientific Support

Answered: 2019-01-01

Question

Will anti-MRP4/ABCC4 antibody A01596 work for WB with leukemic t-cell?

Verified Customer

Verified customer

Asked: 2018-12-25

Answer

According to the expression profile of leukemic t-cell, ABCC4 is highly expressed in leukemic t-cell. So, it is likely that anti-MRP4/ABCC4 antibody A01596 will work for WB with leukemic t-cell.

Boster Scientific Support

Answered: 2018-12-25

Size

Conjugation

Total: $370

SKU:A01596

In stock, 1 left.

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A01596
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

$50 fee for conjugation. Antibody size is reduced to 50ug.

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