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- Table of Contents
3 Citations 1 Q&As
1 Citations 5 Q&As
Facts about Multidrug resistance-associated protein 4.
Human | |
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Gene Name: | ABCC4 |
Uniprot: | O15439 |
Entrez: | 10257 |
Belongs to: |
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ABC transporter superfamily |
ABCC4; ATP-binding cassette sub-family C member 4; ATP-binding cassette, sub-family C (CFTR/MRP), member 4; EST170205; MOATB; MOAT-BbA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4); MOATBcanalicular multispecific organic anion transporter (ABC superfamily); MRP4; MRP4MRP/cMOAT-related ABC transporter; multidrug resistance-associated protein 4; multispecific organic anion transporter B; Multi-specific organic anion transporter B
Mass (kDA):
149.527 kDA
Human | |
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Location: | 13q32.1 |
Sequence: | 13; NC_000013.11 (95019835..95301451, complement) |
Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.
Membrane; Multi-pass membrane protein.
ABCC4 is a highly versatile gene marker that can be used in a variety applications. In this article, we will look at RT-PCR, Detection, Applications, and Molecular Biology. The ABCC4 gene marker is a useful tool for detecting cancers as well as autoimmune diseases and other illnesses. This article will demonstrate how to utilize the ABCC4 gene marker and how you can use it to your advantage.
Patients who suffer from acute myocardial damage have low levels of ABCC4 gene expression in their peripheral blood. This gene expression can be a genetic marker to aid in the diagnosis of acute myocardial infarction. The level of expression of the ABCC4 gene is assessed using real-time fluorescent quantitativePCR. This test can detect levels of mRNA as high as four times lower than the normal level.
The ABCC4 gene, which is located on the chromosome 13,q32.1 encodes the shortest of the ABCC/MRP families. The ABCC/MRP family plays an important part in the efflux of many endogenous as well as endogenous molecules. RT-PCR with the ABCC4 marker is a powerful tool to detect disease-causing agents as well as studying the therapeutic potential of different drugs.
Boster Biologicals provides high-affinity primary antibodies that can be used in diagnostic and research tests. These antibodies have been well-cited for decades and have been validated for use in Western Blotting, Immunohistochemistry, and ELISA. Boster is not the only company to develop kits to make antibodies for the ABCC4 marker but also offers immunological agents that can be utilized in many other applications.
Researchers are investigating the uses of the ABCC4 marker for cancer. This genetic marker has been recently associated with a variety of tumors that include cervical cancer. We previously discovered that ABCC4 is often detected as abnormally expressed in various types of tumors. In this study, we investigated whether ABCC4 is overexpressed in cervical cancer tissue and cell lines. We also looked into the effects of miR-506 on the growth and survival of cervical cancer cells. Western analysis of blots was used to confirm that miR-506 regulates ABCC4.
The ABCC4 protein has been found to be overexpressed in human NK/T lymphoma cells and regulates the sensitivity of chemotherapy. These findings suggest that the ABCC4 protein could be a potential therapeutic target. The ABCC4 protein can be utilized as a base for the development of novel treatments for cancers. The ABCC4 protein is extremely expressed in the human NK/T-cell lymphoma and in many other cancers.
Downregulation of ABCC4 increased susceptibility to ADR and miR124-3p in MCF-7 cancer cells. This dual targeting can enhance breast cancer therapies. Researchers have also discovered ABCC4 in research on cancer as a marker of cell migration and proliferation. They are currently trying to find more effective treatments for cancers of the breast that are resistant to drugs. ABCC4 may also be used to identify genetic mutations that can be linked to resistance to IL-13.
ABCC4 expression is increased in prostate cancer cells from humans in response to chemotherapy. This is consistent with a previous report that discussed the regulation of ABCC4 expression in response to chemotherapy. These oncogenes have been implicated as an underlying malignant phenotype in neuroblastoma. Therefore, it is important to find more effective cancer treatments specifically those that target ABCC4 as a means of prevention or treatment.
The ABCC4 transporter is part of the ABCC subfamily of transporters. They are transmembrane proteins which control the movement of various endogenous and exogenous molecules across cellular membranes. The ABCC4 gene located on chromosome 13,q32.1 is the shortest of the ABCC/MRP families. It plays a role in the efflux and transportation of many endogenous and exogenous substances, as per molecular biology research.
ABCC4 is an essential player in platelet activation. The phosphorylation of ABCC4 from the inner to the outer membrane leaflet results in a catalytic surface in platelet phagocytosis by the spleen. In Stormorken syndrome, ABCC4 is defective. ABCC4 also contributes to prostaglandin-active transport in human platelets. The disease has been connected to ABCC4 inhibition by nonsteroidal anti-inflammatory medications.
Numerous studies have revealed that the ABCC4 gene plays potential role in lung cancer. ABC genes have been shown to be significant regulators of the pharmacological response. In addition to its role in lung cancer, ABCC4 is linked to genetic variation in the development of drug resistance. In addition, some therapeutic tools have been created to raise the expression of ABCC4 against the main transporters that are involved in chemoresistance.
PMID: 9661885 by Lee K., et al. Isolation of MOAT-B, a widely expressed multidrug resistance- associated protein/canalicular multispecific organic anion transporter-related transporter.
PMID: 12105214 by Adachi M., et al. Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing.
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