Anti-MRP4/ABCC4 Antibody Picoband™

MRP4/ABCC4 antibody

Boster Bio Anti-MRP4/ABCC4 Antibody Picoband™ catalog # PB9144. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. Cited in 3 publication(s).

Product Info Summary

SKU: PB9144
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IHC, WB

Product Name

Anti-MRP4/ABCC4 Antibody Picoband™

View all MRP4/ABCC4 Antibodies

SKU/Catalog Number

PB9144

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-MRP4/ABCC4 Antibody Picoband™ catalog # PB9144. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-MRP4/ABCC4 Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # PB9144)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

E.coli-derived human MRP4 recombinant protein (Position: M1-P370).

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PB9144 is reactive to ABCC4 in Human, Mouse, Rat

Applications

PB9144 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

47 kDa

Calculated molecular weight

149.527kDa

Background of MRP4/ABCC4

ABCC4 (Atp-binding cassette, subfamily c, member 4) also known as MRP4 or MOATB, is a protein that in humans is encoded by the ABCC4 gene. It belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. This gene is mapped to chromosome 13q32. ABCC4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of ABCC4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of ABCC4 activity or knockdown of ABCC4 via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. It has been found that ABCC4 contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat
Western blot, 0.1-0.5μg/ml, Human

Validation Images & Assay Conditions

Gene/Protein Information For ABCC4 (Source: Uniprot.org, NCBI)

Gene Name

ABCC4

Full Name

Multidrug resistance-associated protein 4

Weight

149.527kDa

Superfamily

ABC transporter superfamily

Alternative Names

ABCC4; ATP-binding cassette sub-family C member 4; ATP-binding cassette, sub-family C (CFTR/MRP), member 4; EST170205; MOATB; MOAT-BbA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4); MOATBcanalicular multispecific organic anion transporter (ABC superfamily); MRP4; MRP4MRP/cMOAT-related ABC transporter; multidrug resistance-associated protein 4; multispecific organic anion transporter B; Multi-specific organic anion transporter B ABCC4 MOAT-B, MOATB, MRP4 ATP binding cassette subfamily C member 4 multidrug resistance-associated protein 4|MRP/cMOAT-related ABC transporter|bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)|canalicular multispecific organic anion transporter (ABC superfamily)|multi-specific organic anion transporter B

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on ABCC4, check out the ABCC4 Infographic

ABCC4 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for ABCC4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

PB9144 has been cited in 3 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

The Herbal Constituents in An-Gong-Niu-Huang Wan (AGNH) Protect against Cinnabar- and Realgar-Induced Hepatorenal Toxicity and Accumulations of Mercury and Arsenic in Mice

Chen L,Liao L,Zhai T,Huang X,Chen Y.Influence of Orally Administered Borneol on the Expression of Hepatic Transporters in Rats.Eur J Drug Metab Pharmacokinet.2019 Feb;44(1):103-109.doi:10.1007/s13318-018-0499-1.PMID:30105488.
Species: Rat
PB9144 usage in article: APP:WB, SAMPLE:LIVER TISSUE, DILUTION:NA

Songsong Wang,Xiao Xiao,Ao Li,Peng Li,"The Herbal Constituents in An-Gong-Niu-Huang Wan (AGNH) Protect against Cinnabar- and Realgar-Induced Hepatorenal Toxicity and Accumulations of Mercury and Arsenic in Mice",Evidence-Based Complementary and Alternative Medicine,vol.2021,Article ID 5566078,9 pages,2021.https://doi.org/10.1155/2021/5566078
Species: Mouse
PB9144 usage in article: APP: WB, SAMPLE:HEPATORENAL TISSUE, DILUTION:NA

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1 Customer Q&As for Anti-MRP4/ABCC4 Antibody Picoband™

Question

We are currently using anti-MRP4/ABCC4 antibody PB9144 for rat tissue, and we are well pleased with the WB results. The species of reactivity given in the datasheet says human, mouse, rat. Is it true that the antibody can work on zebrafish tissues as well?

Verified Customer

Verified customer

Asked: 2018-03-16

Answer

The anti-MRP4/ABCC4 antibody (PB9144) has not been tested for cross reactivity specifically with zebrafish tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in zebrafish you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2018-03-16

Size

Conjugation

Total: $370

SKU:PB9144

In stock, 3+ left.

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PB9144
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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