Product Info Summary
SKU: | A09989 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Neuritin NRN1 Antibody
SKU/Catalog Number
A09989
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Neuritin NRN1 Antibody (Catalog # A09989). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
Neuritin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Neuritin NRN1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09989)
Host
Rabbit
Contents
Neuritin Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Neuritin antibody was raised against a 20 amino acid synthetic peptide from near the center of human neuritin. The immunogen is located within amino acids 70 - 120 of Neuritin.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least four isoforms are known to exist. ZIMP7 antibody is predicted to not cross-react with other PIAS protein family members.
Reactive Species
A09989 is reactive to NRN1 in Human, Mouse
Applications
A09989 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
15.333kDa
Background of Neuritin
As the nervous system of a complex organism develops, it establishes functional networks through the growth and retraction of synaptic connections from growing axons and dendrites. This synaptic remodeling involves neuro-transmitter signaling, activation of neurotrophin receptors and alterations in gene expression. One such gene whose expression is increased by neural activity is neuritin, a GPI-anchored protein that is expressed in postmitotic differentiating neurons of the developing nervous system. Its expression is also induced by the neurotrophins BDNF and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic neuronal cultures, suggesting that neuritin may play a role as a downstream effector of activity-induced neurite outgrowth. More recent experiments have shown that neuritin is required for the androgen-induced axonal elongation in motor neurons and is upregulated following spinal cord injury, suggesting that neuritin may also play a role in survival and axonal regeneration.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Neuritin antibody can be used for detection of Neuritin by Western blot at 5 and 10 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of neuritin in Daudi cell lysate with neuritin antibody at (A) 5 and (B) 10 μg/mL.
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Immunohistochemistry of Neuritin in mouse heart tissue with Neuritin antibody at 5 μg/mL.
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Immunofluorescence of Neuritin in Mouse Heart cells with Neuritin antibody at 20 μg/mL.
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Immunohistochemistry of Neuritin in human brain tissue with Neuritin antibody at 2.5 μg/ml.
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Immunofluorescence of Neuritin in human brain tissue with Neuritin antibody at 20 μg/mL.
Green: Neuritin Antibody (A09989)
Blue: DAPI staining
Protein Target Info & Infographic
Gene/Protein Information For NRN1 (Source: Uniprot.org, NCBI)
Gene Name
NRN1
Full Name
Neuritin
Weight
15.333kDa
Superfamily
neuritin family
Alternative Names
dJ380B8.2; neuritin 1; Neuritin; NRN1; NRNMGC44811 NRN1 NRN, dJ380B8.2 neuritin 1 neuritin
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on NRN1, check out the NRN1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for NRN1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Neuritin NRN1 Antibody (A09989)
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No publications found for A09989
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Customer Reviews
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