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Product Info Summary
| SKU: | A10045 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Neurotrypsin PRSS12 Antibody
View all Neurotrypsin Antibodies
SKU/Catalog Number
A10045
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Neurotrypsin PRSS12 Antibody (Catalog # A10045). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Neurotrypsin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Neurotrypsin PRSS12 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10045)
Host
Rabbit
Contents
Neurotrypsin Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Neurotrypsin antibody was raised against a 23 amino acid synthetic peptide from near the amino terminus of human neurotrypsin. The immunogen is located within amino acids 110 - 160 of Neurotrypsin.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
PDCL3 antibody is human, mouse and rat reactive. PDCL3 antibody is predicted to not cross-react with other members of the PDCL protein family.
Reactive Species
A10045 is reactive to PRSS12 in Human, Mouse, Rat
Applications
A10045 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
97.067kDa
Background of Neurotrypsin
Neurotrypsin is a central nervous system-expressed serine protease whose truncation or absence causes nonsyndromic mental retardation. It is most prominently expressed in structures that are involved in the processing and storage of learned behavior and memory, such as the cerebral cortex, the hippocampus, and amygdala. Evidence suggests that neurotrypsin has multiple functions, including axonal outgrowth, maintaining neuronal plasticity, and arranging the perineuronal environment, partly in coordination with other proteases including tissue plasminogen activator. At least two isoforms of neurotrypsin are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Neurotrypsin antibody can be used for detection of neurotrypsin by Western blot at 0.5 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of neurotrypsin in 3T3 cell lysate with neurotrypsin antibody at (A) 0.25 and (B) 0.5 μg/mL.
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Immunohistochemistry of Neurotrypsin in human brain tissue with Neurotrypsin antibody at 2.5 μg/mL.
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Immunofluorescence of Neurotrypsin in Human Brain cells with Neurotrypsin antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For PRSS12 (Source: Uniprot.org, NCBI)
Gene Name
PRSS12
Full Name
Neurotrypsin
Weight
97.067kDa
Superfamily
peptidase S1 family
Alternative Names
brain-specific serine protease 3; BSSP3; BSSP-3; EC 3.4.21; Leydin; MGC12722; Motopsin; MRT1EC 3.4.21.-; neurotrypsin; protease, serine, 12 (neurotrypsin, motopsin); Serine protease 12 PRSS12 BSSP-3, BSSP3, MRT1 serine protease 12 neurotrypsin|brain-specific serine protease 3|leydin|protease, serine 12|protease, serine, 12 (neurotrypsin, motopsin)
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PRSS12, check out the PRSS12 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PRSS12: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Neurotrypsin PRSS12 Antibody (A10045)
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