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Anti-P53 Tp53 Monoclonal Antibody

Boster Bio Anti-P53 Tp53 Monoclonal Antibody catalog # MA1078. Tested in IHC, ICC, WB applications. This antibody reacts with Human. Supplied as 100μg/vial in Lyophilized form antibody. Cited in 50 publication(s).

Publications (50)
Q&As (4)
Datasheet
Protocols
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Figure 1. Western blot analysis of p53 using anti-p53 antibody (MA1078).

Figure 2. IHC analysis of p53 using anti-p53 antibody (MA1078).

Figure 3. IF analysis of p53 using anti-p53 antibody (MA1078).

Anti-P53 Tp53 Monoclonal Antibody Product Summary

SKU:	MA1078
Size:	100μg/vial
Reactivity:	Human
Clonality:	Monoclonal
Clone Number:	BP53-12
Host:	Mouse
Applications:	IHC, ICC, WB
Conjugation:	Choose a conjugate option when adding to cart. Sample size cannot be ordered with conjugation. Conjugated antibody size will be reduced in half due to loss in the conjugation process.

Product Info

Overview

Product Name	Anti-P53 Tp53 Monoclonal Antibody See more p53 products
Catalog#	MA1078
Pack Size	100μg/vial
Storage & Handling	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Description	Boster Bio Anti-P53 Tp53 Monoclonal Antibody catalog # MA1078. Tested in IHC, ICC, WB applications. This antibody reacts with Human. Supplied as 100μg/vial in Lyophilized form antibody.
Cite This Product	Anti-P53 Tp53 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # MA1078)
Antibodies Validation	Antibodies Validation Information
Similar Products From Other Companies	Anti-P53 Tp53 Monoclonal Antibody may replace the following items: sc 100350\|sc 10840\|sc 10843\|sc 126\|sc 126 X\|sc 12904 R\|sc 1311 R\|sc 135772\|sc 135772 X\|sc 135773\|sc 135773 X\|sc 136832\|sc 137173\|sc 137174\|sc 137175\|sc 139542\|sc 139543\|sc 16715 R\|sc 16716 R\|sc 17105 R\|sc 17106 R\|sc 17274 R\|sc 18079 R\|sc 21872 R\|sc 22785\|sc 244647\|sc 244648\|sc 249070\|sc 249071\|sc 376973\|sc 398705\|sc 48262\|sc 514582\|sc 514703\|sc 6243 G\|sc 6243 X\|sc 67184\|sc 71783\|sc 71784\|sc 71785\|sc 71786\|sc 71817 X\|sc 7997 R\|sc 7997 X\|sc 81511\|sc 85846\|sc 85848\|sc 85975\|sc 98 X\|sc 98384.

Product Specs

Host	Mouse
Reactive Species	Human
Applications	IHC, ICC, WB *Our Boster Guarantee covers the use of this product in the above tested applications. *Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
Related Products	Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(P), IHC(F) and ICC. Blocking peptide can be purchased at $100. Contact us for more information. *Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
Immunogen	Recombinant human wild-type p53 protein.
Cross Reactivity	No cross reactivity with other proteins

Protein Target Info

Gene/Protein Basic Information For Tp53 (Source: Uniprot.org, NCBI)

Uniprot Id	P10361
NCBI Gene Id	24842
Species Of This Entry	Rat
Gene Name	Tp53
Protein Name	Cellular tumor antigen p53
Superfamily	p53 family
Alternative Names	p53\|Antigen NY-CO-13; BCC7; FLJ92943; LFS1; LFS1TRP53; p53 tumor suppressor; p53; P53cellular tumor antigen p53; Phosphoprotein p53; TP53; transformation-related protein 53; TRP53; tumor protein p53; Tumor suppressor p53
Molecular Weight	43451

*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".

For more info on Tp53, check out the Tp53 Infographic

We have 30,000+ of these available, one for each gene! Check them out.

Want a nice infographic on your next protein? Boster's got them all. All proteins in the human genome, and some, can be found in the Boster Bio gene infographics. Download it and share it with your colleagues and friends. Big size posters available upon request.

In this infographic you will see the following information for Tp53: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. Some times it even contains some opt-ed articles the Boster team on the scientific news and clinical impacts of this protein, though not all have that. Too many proteins, you know.

Take me to the Tp53 infographic

Assay Dilutions Overview

Our Boster Quality Guarantee for Anti-P53 Tp53 Monoclonal Antibody covers its use in the following applications.

Immunohistochemistry (Paraffin-embedded Section), 0.5-2μg/ml, Human, By Heat
Immunocytochemistry , 1μg/ml, Human, -
Immunohistochemistry (Frozen Section), 0.5-2μg/ml, Human, -
Western blot, 0.5-1μg/ml, Human

*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.

Images & QC Assay Conditions

Figure 1. Western blot analysis of p53 using anti-p53 antibody (MA1078).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
Lane 1: HL-60 whole cell lysates,
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with mouse anti-p53 antigen affinity purified monoclonal antibody (Catalog # MA1078) at 0.5 μg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-mouse IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1001) with Tanon 5200 system. A specific band was detected for p53 at approximately 53KD. The expected band size for p53 is at 53KD.

Figure 2. IHC analysis of p53 using anti-p53 antibody (MA1078).
p53 was detected in paraffin-embedded section of human mammary cancer tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1μg/ml mouse anti-p53 Antibody (MA1078) overnight at 4°C. Biotinylated goat anti-mouse IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1021) with DAB as the chromogen.

Figure 3. IF analysis of p53 using anti-p53 antibody (MA1078).
p53 was detected in immunocytochemical section of A431 cell. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent (AR0022) for 15 mins. The cells were blocked with 10% goat serum. And then incubated with 2μg/mL mouse anti-p53 Antibody (MA1078) overnight at 4°C. DyLight®488 Conjugated Goat Anti-Mouse IgG (BA1126) was used as secondary antibody at 1:100 dilution and incubated for 30 minutes at 37°C. The section was counterstained with DAPI. Visualize using a fluorescence microscope and filter sets appropriate for the label used.

Specific Protocols

Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.

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Publications

Total number of citations: 50

Huixia Zhang,Mengda Liu,Hui Zhang et al.Detection of p53 mutation and serum monitoring alert caused by Marek‘s disease virus, 11 May 2020, PREPRINT (Version 2) available at Research Square [https://doi.org/10.21203/rs.2.23898/v2] Species: SPF Chicken MA1078 usage in article: APP:IHC, SAMPLE:LIVER,SPLEEN,PANCREAS AND BURSA OF FABRICIUS, DILUTION:1:200	View Publication
Jiang X,Yuan J,Dou Y,Zeng D, Xiao S.Lipopolysaccharide Affects the Proliferation and Glucose Metabolism of Cervical Cancer Cells Through the FRA1/MDM2/p53 Pathway.Int J Med Sci 2021;18(4): 1030-1038.doi:10. 7150/ijms.47360. Species: Human MA1078 usage in article: APP:WB, SAMPLE:CASKI CELL AND HELA CELL, DILUTION:NA	View Publication
The natural compound GL22, isolated from Ganoderma mushrooms, suppresses tumor growth by altering lipid metabolism and triggering cell death	PubMed ID 29880886
Metronomic chemotherapy remodel cancer-associated fibroblasts to decrease chemoresistance of gastric cancer in nude mice	PubMed ID 29344235
Acetazolamide Suppresses Multi-Drug Resistance-Related Protein 1 and P-Glycoprotein Expression by Inhibiting Aquaporins Expression in a Mesial Temporal Epilepsy Rat Model	PubMed ID 29217817
Piwil2 is reactivated by HPV oncoproteins and initiates cell reprogramming via epigenetic regulation during cervical cancer tumorigenesis	PubMed ID 27602489
P-glycoprotein Mediates Postoperative Peritoneal Adhesion Formation by Enhancing Phosphorylation of the Chloride Channel-3	PubMed ID 26877779
Effects of human umbilical cord mesenchymal stem cell transplantation combined with minimally invasive hematoma aspiration on intracerebral hemorrhage in rats.	PubMed ID 26807166
Lactotransferrin expression is downregulated and affects the mitogen-activated protein kinase pathway in gastric cancer	PubMed ID 26137081
Correlation ofp53gene mutation and expression of P53 protein in cholangiocarcinoma	PubMed ID 25466963
MDM4 Overexpressed in Acute Myeloid Leukemia Patients with Complex Karyotype and Wild-TypeTP53	PubMed ID 25405759
Suspension culture combined with chemotherapeutic agents for sorting of breast cancer stem cells	PubMed ID 18477410
The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum	PubMed ID 27232757
A novel polysaccharide from Sargassum integerrimum induces apoptosis in A549 cells and prevents angiogensis in vitro and in vivo	PubMed ID 27216943
TALENs-directed?knockout?of the?full-length?transcription?factor?Nrf1? that?represses?malignantbehaviour?of?human?hepatocellular?carcinoma?(HepG2)?cells	PubMed ID 27065079
HOXB1 Is a Tumor Suppressor Gene Regulated by miR-3175 in Glioma	PubMed ID 26565624
Dietary NiCl2 causes G2/M cell cycle arrest in the broiler's kidney	PubMed ID 26440151
Expression of TP53, BCL-2, and VEGFA Genes in Esophagus Carcinoma and its Biological Significance	PubMed ID 26439224
Effect of ligustilide on Ang II-induced hypertrophy in cardiomyocytes and the potential mechanisms	PubMed ID 24944617
c?Ski activates cancer?associated fibroblasts to regulate breast cancer cell invasion	PubMed ID 24011664
Liao S, Xiao S, Chen H, Zhang M, Chen Z, Long Y, Gao L, He J, Ge Y, Yi W, Wu M, Li G, Zhou Y. Int J Oncol. 2017 Nov;51(5):1497-1507. doi: 10.3892/ijo.2017.4137. Epub 2017 Sep 27. The receptor for activated protein kinase C promotes cell growth, in...	PubMed ID 29048616
Feng D, Wu J, Tian Y, Zhou H, Zhou Y, Hu W, Zhao W, Wei H, Ling B, Ma C. Plos One. 2013 Nov 19;8(11):E80657. Doi: 10.1371/Journal.Pone.0080657. Ecollection 2013. Targeting Of Histone Deacetylases To Reactivate Tumour Suppressor Genes And Its Thera...	PubMed ID 24260446
Li W, Wu D, Wei B, Wang S, Sun H, Li X, Zhang F, Zhang C, Xin Y. Afr J Tradit Complement Altern Med. 2014 Aug 23;11(5):99-104. Ecollection 2014. Anti-Tumor Effect Of Cactus Polysaccharides On Lung Squamous Carcinoma Cells (Sk-Mes-1).	PubMed ID 25395712
Zhang F, Kong Ds, Zhang Zl, Lei N, Zhu Xj, Zhang Xp, Chen L, Lu Y, Zheng Sz. Apoptosis. 2013 Feb;18(2):135-49. Doi: 10.1007/S10495-012-0791-5. Tetramethylpyrazine Induces G0/G1 Cell Cycle Arrest And Stimulates Mitochondrial-Mediated And Caspase-De...	PubMed ID 23247439
Guan Yq, Li Z, Yang A, Huang Z, Zheng Z, Zhang L, Li L, Liu Jm. Biomaterials. 2012 Sep;33(26):6162-71. Doi: 10.1016/J.Biomaterials.2012.05.037. Epub 2012 Jun 8. Cell Cycle Arrest And Apoptosis Of Ovcar-3 And Mcf-7 Cells Induced By Co-Immobilized T...	PubMed ID 22682938
Yuan H, Jiang F, Wang R, Shen M, Chen N. Mol Med Rep. 2012 Feb;5(2):420-6. Doi: 10.3892/Mmr.2011.668. Epub 2011 Nov 7. Lentivirus-Mediated Rna Interference Of E2F-1 Suppresses Tca8113 Cell Proliferation.	PubMed ID 22076063
Qin D, He X, Wang K, Zhao Xj, Tan W, Chen J. J Biomed Biotechnol. 2007;2007(7):89364. Doi: 10.1155/2007/89364. Fluorescent Nanoparticle-Based Indirect Immunofluorescence Microscopy For Detection Of Mycobacterium Tuberculosis.	PubMed ID 18273415
Gu T, Li Cx, Feng Y, Wang Q, Li Ch, Li Cf. World J Gastroenterol. 2007 Apr 14;13(14):2113-7. Trans-Arterial Gene Therapy For Hepatocellular Carcinoma In A Rabbit Model.	PubMed ID 17465458
Liu Xm, Yang Ff, Yuan Yf, Zhai R, Huo Lj. Plos One. 2013 May 16;8(5):E63680. Doi: 10.1371/Journal.Pone.0063680. Print 2013. Sumoylation Of Mouse P53B By Sumo-1 Promotes Its Pro-Apoptotic Function In Ovarian Granulosa Cells.	PubMed ID 23696846
Bai J, Lei P, Zhang J, Zhao C, Liang R. Toxicology. 2013 Oct 4;312:142-8. Doi: 10.1016/J.Tox.2013.08.004. Epub 2013 Aug 21. Sulfite Exposure-Induced Hepatocyte Death Is Not Associated With Alterations In P53 Protein Expression.	PubMed ID 23973939
Li W, Wang W, Li Y, Wang W, Wang T, Li L, Han Z, Wang S, Ma D, Wang H. Plos One. 2014 Mar 12;9(3):E90114. Doi: 10.1371/Journal.Pone.0090114. Ecollection 2014. Proteomics Analysis Of Normal And Senescent Ng108-15 Cells: Grp78 Plays A Negative Role ...	PubMed ID 24621580
Li W, Wang W, Dong H, Li Y, Li L, Han L, Han Z, Wang S, Ma D, Wang H. Oncol Rep. 2014 Jun;31(6):2525-34. Doi: 10.3892/Or.2014.3147. Epub 2014 Apr 23. Cisplatin-Induced Senescence In Ovarian Cancer Cells Is Mediated By Grp78.	PubMed ID 24756776
Zhou L, Yang Y, Tian D, Wang Y. Oncol Rep. 2013 Mar;29(3):875-84. Doi: 10.3892/Or.2013.2227. Epub 2013 Jan 4. Oxidative Stress-Induced 1, N6-Ethenodeoxyadenosine Adduct Formation Contributes To Hepatocarcinogenesis.	PubMed ID 23292006
Li Yj, Zhang Yx, Wang Py, Chi Yl, Zhang C, Ma Y, Lv Cj, Xie Sy. Oncol Rep. 2012 Jan;27(1):129-34. Doi: 10.3892/Or.2011.1466. Epub 2011 Sep 20. Regression Of A549 Lung Cancer Tumors By Anti-Mir-150 Vector.	PubMed ID 21935578
Liang S, Peng X, Li X, Yang P, Xie L, Li Y, Du C, Zhang G. Oncotarget. 2015 Jan 20;6(2):1020-30. Silencing Of Cxcr4 Sensitizes Triple-Negative Breast Cancer Cells To Cisplatin.	PubMed ID 25544759
Hao Y, Huang W, Liao M, Zhu Y, Liu H, Hao C, Liu G, Zhang G, Feng H, Ning X, Li H, Li Z. Fitoterapia. 2013 Apr;86:84-91. Doi: 10.1016/J.Fitote.2013.02.005. Epub 2013 Feb 18. The Inhibition Of Resveratrol To Human Skin Squamous Cell Carcinoma A431 ...	PubMed ID 23428654
Liao S, Xiao S, Zhu G, Zheng D, He J, Pei Z, Li G, Zhou Y. Oncol Rep. 2014 Dec;32(6):2703-9. Doi: 10.3892/Or.2014.3537. Epub 2014 Oct 10. Cd38 Is Highly Expressed And Affects The Pi3K/Akt Signaling Pathway In Cervical Cancer.	PubMed ID 25310288
Xiao S, Zhou Y, Yi W, Luo G, Jiang B, Tian Q, Li Y, Xue M. Int J Oncol. 2015 Apr;46(4):1677-84. Doi: 10.3892/Ijo.2015.2873. Epub 2015 Feb 4. Fra-1 Is Downregulated In Cervical Cancer Tissues And Promotes Cervical Cancer Cell Apoptosis By P53 Signa...	PubMed ID 25651840
Zhang J, Chen X, Shi G, Xie X, Liu H, Zhang X, Lai Y, Zuo Y, Chen Z, Liu S, Wang H. J Ovarian Res. 2013 Feb 6;6(1):9. Doi: 10.1186/1757-2215-6-9. Establishment Of A New Representative Model Of Human Ovarian Cancer In Mice.	PubMed ID 23384043
Jiang R, Xu W, Zhu W, Chen M, Qian H, Qiao C, Yang H, Wang X, Chen Y. Oncol Rep. 2006 Nov;16(5):1021-8. Histological Type Of Oncogenity And Expression Of Cell Cycle Genes In Tumor Cells From Human Mesenchymal Stem Cells.	PubMed ID 17016587
Li Bh, Xu Sb, Li F, Zou Xg, Saimaiti A, Simayi D, Wang Yh, Zhang Y, Yuan J, Zhang Wj. Cell Signal. 2012 Mar;24(3):718-25. Doi: 10.1016/J.Cellsig.2011.11.005. Epub 2011 Nov 13. Stat6 Activity-Related Th2 Cytokine Profile And Tumor Growth Advantage ...	PubMed ID 22108090
Zhang S, Zhang C, Li Y, Wang P, Yue Z, Xie S. Biomed Pharmacother. 2011 Sep;65(6):436-42. Doi: 10.1016/J.Biopha.2011.04.010. Epub 2011 Jun 12. Mir-98 Regulates Cisplatin-Induced A549 Cell Death By Inhibiting Tp53 Pathway.	PubMed ID 21880462
Xie Sy, Li Yj, Wang Py, Jiao F, Zhang S, Zhang Wj. Oncol Rep. 2010 Jun;23(6):1693-700. Mirna-Regulated Expression Of Oncogenes And Tumor Suppressor Genes In The Cisplatin-Inhibited Growth Of K562 Cells.	PubMed ID 20428827
Zhang D, Fu M, Song C, Wang C, Lin X, Liu Y. Neural Regen Res. 2012 Oct 25;7(30):2347-53. Doi: 10.3969/J.Issn.1673-5374.2012.30.004. Expressions Of Apoptosis-Related Proteins In Rats With Focal Cerebral Ischemia After Angong Niuhuang Sticker Point...	PubMed ID 25538759
Yang S, Wang H, Guo Y, Chen S, Zhang My, Shen J, Yu H, Miao J, Wang Hy, Wei W. Int J Biol Sci. 2013 Jul 5;9(6):637-48. Doi: 10.7150/Ijbs.6439. Print 2013. Rmp Plays Distinct Roles In The Proliferation Of Hepatocellular Carcinoma Cells And Normal H...	PubMed ID 23847445
Dong Hy, Wang Zf. Chin J Cancer Res. 2014 Apr;26(2):200-7. Doi: 10.3978/J.Issn.1000-9604.2014.04.07. Antitumor Effects Of Artesunate On Human Breast Carcinoma Mcf-7 Cells And Igf-Ir Expression In Nude Mice Xenografts.	PubMed ID 24826061
Wang Q, Xu Y, Zhou W, Zhong L, Wen Z, Yu H, Chen S, Shen J, Chen H, She Q, Jiang J, Miao J, Wei W. Int J Biol Sci. 2014 Nov 18;10(10):1181-92. Doi: 10.7150/Ijbs.10275. Ecollection 2014. The Viral Oncoprotein Hbx Of Hepatitis B Virus Promotes The G...	PubMed ID 25516716
Guo H, Nan K, Hu T, Meng J, Hui W, Zhang X, Qin H, Sui C. Hepatol Res. 2010 Nov;40(11):1107-16. Doi: 10.1111/J.1872-034X.2010.00721.X. Epub 2010 Sep 28. Prognostic Significance Of Co-Expression Of Nm23 And P57 Protein In Hepatocellular Carcinoma.	PubMed ID 20880063
Li B, Chu X, Gao M, Li W. Acta Biochim Biophys Sin (Shanghai). 2010 Jan;42(1):80-9. Apoptotic Mechanism Of Mcf-7 Breast Cells In Vivo And In Vitro Induced By Photodynamic Therapy With C-Phycocyanin.	PubMed ID 20043050
Jiang H, Li J, Zhou T, Wang C, Zhang H, Wang H. Int J Mol Med. 2014 May;33(5):1298-304. Doi: 10.3892/Ijmm.2014.1684. Epub 2014 Mar 6. Colistin-Induced Apoptosis In Pc12 Cells: Involvement Of The Mitochondrial Apoptotic And Death Receptor Pathways.	PubMed ID 24604244

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Customer Q&As

Questions and answers from customers related to MA1078 Anti-P53 Tp53 Monoclonal Antibody

4 Related Questions

Question

We have seen staining in human embryonic kidney. Are there any suggestions? Is anti-P53 Monoclonal antibody supposed to stain embryonic kidney positively?

Verified Customer

Asked: 2019-11-05

Answer

From what I have seen in literature embryonic kidney does express TP53. From what I have seen in Uniprot.org, TP53 is expressed in epithelium of mammary gland, colon, kidney, lung carcinoma, blood, ovarian adenocarcinoma, glial cell glial tumor, embryonic kidney, among other tissues. Regarding which tissues have TP53 expression, here are a few articles citing expression in various tissues:
Colon, Pubmed ID: 16131611
Embryonic kidney, Pubmed ID: 17525332
Glial cell, and Glial tumor, Pubmed ID: 19011621
Kidney, Pubmed ID: 15489334
Lung carcinoma, Pubmed ID: 14660794

Boster Scientific Support

Answered: 2019-11-05

Question

We are currently using anti-P53 Monoclonal antibody MA1078 for human tissue, and we are satisfied with the ICC results. The species of reactivity given in the datasheet says human. Is it true that the antibody can work on feline tissues as well?

Verified Customer

Asked: 2019-09-19

Answer

The anti-P53 Monoclonal antibody (MA1078) has not been validated for cross reactivity specifically with feline tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in feline you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2019-09-19

Question

We bought anti-P53 Monoclonal antibody for IHC on ovarian adenocarcinoma in a previous experiment. I am using human, and We are going to use the antibody for ICC next. I would like examining ovarian adenocarcinoma as well as glial cell glial tumor in our next experiment. Could you please give me some suggestion on which antibody would work the best for ICC?

Verified Customer

Asked: 2018-05-29

Answer

I have checked the website and datasheets of our anti-P53 Monoclonal antibody and I see that MA1078 has been tested on human in both IHC and ICC. Thus MA1078 should work for your application. Our Boster satisfaction guarantee will cover this product for ICC in human even if the specific tissue type has not been validated. We do have a comprehensive range of products for ICC detection and you can check out our website bosterbio.com to find out more information about them.

Boster Scientific Support

Answered: 2018-05-29

Question

My team were content with the WB result of your anti-P53 Monoclonal antibody. However we have seen positive staining in kidney cytoplasm using this antibody. Is that expected? Could you tell me where is TP53 supposed to be expressed?

D. Krishna

Asked: 2016-09-21

Answer

Based on literature, kidney does express TP53. Generally TP53 expresses in cytoplasm. Regarding which tissues have TP53 expression, here are a few articles citing expression in various tissues:
Colon, Pubmed ID: 16131611
Embryonic kidney, Pubmed ID: 17525332
Glial cell, and Glial tumor, Pubmed ID: 19011621
Kidney, Pubmed ID: 15489334
Lung carcinoma, Pubmed ID: 14660794

Boster Scientific Support

Answered: 2016-09-21

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Note: sample size takes longer to process, average 5-7 days.

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Comprehensive info on Tp53, beautifully presented.

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Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)

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Anti-P53 Tp53 Monoclonal Antibody

Anti-P53 Tp53 Monoclonal Antibody Product Summary

Overview

Product Specs

Gene/Protein Basic Information For Tp53 (Source: Uniprot.org, NCBI)

For more info on Tp53, check out the Tp53 Infographic

We have 30,000+ of these available, one for each gene! Check them out.

Specific Protocols

Did You Know ?

Other Recommended Resources

Total number of citations: 50

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Questions and answers from customers related to MA1078 Anti-P53 Tp53 Monoclonal Antibody

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