Product Info Summary
SKU: | A04104 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | IHC, WB |
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Product info
Product Name
Anti-Paraplegin SPG7 Antibody
SKU/Catalog Number
A04104
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Paraplegin SPG7 Antibody catalog # A04104. Tested in WB,IHC applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Paraplegin SPG7 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04104)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human IGFBP6.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A04104 is reactive to SPG7 in Human, Mouse, Rat
Applications
A04104 is guaranteed for IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
88.235kDa
Background of SPG7
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons By similarity.
Mitsutoshi Nakada, Cancer Res., Sep 2006; 66: 8492 - 8500.
Klas Kullander, Genes & Dev., Apr 2001; 15: 877.
M. Douglas Benson, PNAS, Jul 2005; 102: 10694 - 10699.
Stephanie R. Kadison, J. Neurosci., Aug 2006; 26: 8909 - 8914.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:1000-1:2000
IHC: 1:50-1:200
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Western blotting validation for Anti-Paraplegin SPG7 Antibody A04104
Western blot analysis of extract of various cellsProtein Target Info & Infographic
Gene/Protein Information For SPG7 (Source: Uniprot.org, NCBI)
Gene Name
SPG7
Full Name
Paraplegin
Weight
88.235kDa
Alternative Names
CARMGC126331; cell matrix adhesion regulator; CMARMGC126332; EC 3.4.24; EC 3.4.24.-; FLJ37308; paraplegin; PGNcell adhesion regulator; spastic paraplegia 7 (pure and complicated autosomal recessive); Spastic paraplegia 7 protein; SPG5C SPG7 CAR, CMAR, PGN, SPG5C SPG7 matrix AAA peptidase subunit, paraplegin paraplegin|SPG7, paraplegin matrix AAA peptidase subunit|cell matrix adhesion regulator|spastic paraplegia 7 (pure and complicated autosomal recessive)|spastic paraplegia 7 protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SPG7, check out the SPG7 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SPG7: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Paraplegin SPG7 Antibody (A04104)
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No publications found for A04104
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Customer Reviews
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