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Product Info Summary
| SKU: | A08481-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-PARC CUL9 Antibody
SKU/Catalog Number
A08481-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-PARC CUL9 Antibody (Catalog # A08481-1). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
PARC antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-PARC CUL9 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08481-1)
Host
Rabbit
Contents
PARC Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
PARC antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human PARC. The immunogen is located within the last 50 amino acids of PARC.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
GLIPR1 antibody is human and mouse reactive. At least two isoforms of GLIPR1 are known to exist; this antibody will detect both isoforms. This antibody is predicted to not cross-react with other GLIPR or GLIPR-like proteins.
Reactive Species
A08481-1 is reactive to CUL9 in Human, Mouse
Applications
A08481-1 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
281.229kDa
Background of PARC
The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor. PARC, a large, Parkin-like ubiquitin ligase has recently been identified as a cytoplasmic anchor protein in p53-associated protein complexes. In the absence of stress, PARC inactivation results in nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression of this protein promoted cytoplasmic sequestration of p53. Surprisingly, PARC knockout mice were viable and exhibited no obvious phenotype, suggesting that other proteins, such as the highly related cullin family of E3 ubiquitin ligases, may perform similar functions in the absence of PARC. Additionally, it has been suggested that p53 binding to PARC may serve to control PARC function.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
PARC antibody can be used for the detection of PARC by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 1 μg/mL. For immunofluorescence start at 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of PARC in Daudi lysate with PARC antibody at (A) 1 and (B) 2 μg/mL.
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Immunocytochemistry of Parc in Daudi cells with Parc antibody at 1 μg/mL.
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Immunofluorescence of Bcl-G in Daudi cells with Bcl-G antibody at 2 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For CUL9 (Source: Uniprot.org, NCBI)
Gene Name
CUL9
Full Name
Cullin-9
Weight
281.229kDa
Superfamily
cullin family
Alternative Names
CUL-9; cullin 9; cullin-9; DKFZp686G1042; H7AP1DKFZp686P2024; p53-associated parkin-like cytoplasmic protein; PARCKIAA0708; parkin-like cytoplasmic p53 binding protein; RP3-330M21.2; UbcH7-associated protein 1 CUL9 H7AP1, PARC cullin 9 cullin-9|CUL-9|UbcH7-associated protein 1|p53-associated parkin-like cytoplasmic protein|parkin-like cytoplasmic p53 binding protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CUL9, check out the CUL9 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CUL9: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-PARC CUL9 Antibody (A08481-1)
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