Anti-PDCD5 Antibody

Product Name

Anti-PDCD5 Antibody

View all PDCD5 Antibodies

SKU/Catalog Number

A02516-2

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-PDCD5 Antibody (Catalog # A02516-2). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

PDCD5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-PDCD5 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02516-2)

Host

Rabbit

Contents

PDCD5 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

PDCD5 antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human PDCD5. The immunogen is located within the first 50 amino acids of PDCD5.

Reactive Species

A02516-2 is reactive to PDCD5 in Human, Mouse, Rat

Observed Molecular Weight

21 kDa

Calculated molecular weight

14.3 kDa

Background of PDCD5

Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5'-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A02516-2 is guaranteed for ELISA, ICC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

PDCD5 antibody can be used for detection of PDCD5 by Western blot at 2.5 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information PDCD5

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