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Product Info Summary
| SKU: | A04900-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-Protein lifeguard 2 FAIM2 Antibody
SKU/Catalog Number
A04900-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Protein lifeguard 2 FAIM2 Antibody (Catalog # A04900-1). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
FAIM2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Protein lifeguard 2 FAIM2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04900-1)
Host
Rabbit
Contents
FAIM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
FAIM2 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human FAIM2. The immunogen is located within the first 50 amino acids of FAIM2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
A lower band at approximately 16 kDa was detected in Daudi and K562 cells, which may represent the PUMA isoform 2.
Reactive Species
A04900-1 is reactive to FAIM2 in Human, Mouse, Rat
Applications
A04900-1 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
35.11kDa
Background of FAIM2
Programmed cell death regulates a number of biological processes such as normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. FAIM2 is a recently identified protein that can inhibit the apoptotic signal transduced by the Fas receptor but not from the related tumor necrosis factor-alpha death signal. In this respect, FAIM2 is functionally similar to the anti-apoptotic proteins FAIM, FLIP and Bcl-xL. FAIM2, a seven membrane spanning protein, can bind the Fas receptor but does not regulate Fas expression or inhibit binding of FADD to Fas. FAIM2 is widely distributed, but highly expressed in the hippocampus and other neural tissues. FAIM2 was also identified as the neural membrane protein 35 (NMP35) and its expression is known to be regulated by the Phosphatidylinositol 3-kinase-Akt/PKB pathway.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
FAIM2 antibody can be used for detection of FAIM2 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of FAIM2 in EL4 cell lysate with FAIM2 antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunohistochemistry of FAIM2 in mouse brain tissue with FAIM2 antibody at 5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For FAIM2 (Source: Uniprot.org, NCBI)
Gene Name
FAIM2
Full Name
Protein lifeguard 2
Weight
35.11kDa
Superfamily
BI1 family
Alternative Names
Fas apoptotic inhibitory molecule 2; KIAA0950NGP35; LFG2; LFGLIFEGUARD; NMP35neural membrane protein 35; Protein lifeguard; TMBIM2lifeguard; transmembrane BAX inhibitor motif containing 2; Transmembrane BAX inhibitor motif-containing protein 2 FAIM2 LFG, LFG2, NGP35, NMP35, TMBIM2 Fas apoptotic inhibitory molecule 2 protein lifeguard 2|neural membrane protein 35|transmembrane BAX inhibitor motif-containing protein 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on FAIM2, check out the FAIM2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for FAIM2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Protein lifeguard 2 FAIM2 Antibody (A04900-1)
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No publications found for A04900-1
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