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Product Info Summary
| SKU: | A13697 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Rkhd1 MEX3D Antibody
SKU/Catalog Number
A13697
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Rkhd1 MEX3D Antibody (Catalog # A13697). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Storage & Handling
Rkhd1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Rkhd1 MEX3D Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A13697)
Host
Rabbit
Contents
Rkhd1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Rkhd1 antibody was raised against a 15 amino acid synthetic peptide from near the center of human Rkhd1. The immunogen is located within amino acids 360 - 410 of Rkhd1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of Paralemmin3 are known to exist; this antibody will only detect the longer isoform
Reactive Species
A13697 is reactive to Mex3d in Human
Applications
A13697 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
65.329kDa
Background of Mex3d
Rkhd1, also known as TINO or MEX3D is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd1, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. Rkhd1 binds to the AU-rich element in the 3'-untranslated region of Bcl-2 mRNA and is thought to be a negative regulator of Bcl-2 expression. Rkhd3 and Rkhd4, but not Rkhd1, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Rkhd1 antibody can be used for detection of Rkhd1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Rkhd1 in MDA-MB-361 cell lysate with Rkhd1 antibody at (A) 1 μg/ml and (B) 2 μg/mL.
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Immunohistochemistry of Rkhd1 in human small intestine tissue with Rkhd1 antibody at 2.5 μg/mL.
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Immunofluorescence of rkhd1 in human small intestine tissue with rkhd1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For Mex3d (Source: Uniprot.org, NCBI)
Gene Name
Mex3d
Full Name
RNA-binding protein MEX3D
Weight
65.329kDa
Alternative Names
KIAA2031Tino; mex-3 homolog D (C. elegans); OK/SW-cl.4; ring finger (C3HC4 type) and KH domain containing 1; ring finger and KH domain containing 1; RING finger and KH domain-containing protein 1; RING finger protein 193; RKHD1MEX3; RNA-binding protein MEX3D; RNF193MEX-3D; TINObcl-2 ARE RNA binding protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Mex3d, check out the Mex3d Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Mex3d: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Rkhd1 MEX3D Antibody (A13697)
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No publications found for A13697
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