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Product Info Summary
| SKU: | A11204 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-RUSC1 Antibody
SKU/Catalog Number
A11204
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-RUSC1 Antibody (Catalog # A11204). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
RUSC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-RUSC1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A11204)
Host
Rabbit
Contents
RUSC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
RUSC1 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human RUSC1. The immunogen is located within amino acids 780 - 830 of RUSC1.
Reactive Species
A11204 is reactive to RUSC1 in Human, Mouse, Rat
Observed Molecular Weight
68 kDa
Calculated molecular weight
96.4 kDa
Background of RUSC1
RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with IκB kinase- (IKK-) gamma, the regulatory subunit of the IKK complex that is required for NF-κB activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-κB activation pathway.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A11204 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
RUSC1 antibody can be used for detection of RUSC1 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of RUSC1 in A-20 cell lysate with RUSC1 antibody at 1 μg/mL.
Specific Publications For Anti-RUSC1 Antibody (A11204)
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