Anti-SCO1 Antibody

Product Name

Anti-SCO1 Antibody

View all SCO1 Antibodies

SKU/Catalog Number

A02934

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-SCO1 Antibody (Catalog # A02934). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

SCO1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-SCO1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02934)

Host

Rabbit

Contents

SCO1 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

SCO1 antibody was raised against a 14 amino acid synthetic peptide from near the center of human SCO1. The immunogen is located within amino acids 100 - 150 of SCO1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

ANGPTL3 antibody is human, mouse and rat reactive. ANGPTL3 antibody is predicted not to cross-react with other ANGPTL family proteins.

Reactive Species

A02934 is reactive to SCO1 in Human, Mouse, Rat

Applications

A02934 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

33.814kDa

Background of SCO1

Synthesis of cytochrome c oxidase 1 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO1 and SCO2 are dependent on copper ion binding. Mutations in either gene can lead to cytochrome c oxidase respiratory chain defects, with a missense mutation in human SCO1 (P174L) associated with a fatal neonatal hepatopathy when the second allele is also non-functional, suggesting the pathology is due to loss of function. It has been suggested that this mutation alters the SCO1 affinity for the copper (I) ion, thus impairing the efficiency of copper transfer to the cytochrome c oxidase. At least two isoforms of SCO1 are known to exist and both are recognized by the SCO1 antibody. This SCO1 antibody has no cross-reactivity to SCO2.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

SCO1 antibody can be used for detection of SCO1 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot analysis of SCO1 in human brain tissue lysate with SCO1 antibody at (A) 0.5 and (B) 1 μg/mL.

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Immunohistochemistry of SCO1 in human brain tissue with SCO1 antibody at 2.5 μg/mL.

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Immunofluorescence of SCO1 in Human Brain cells with SCO1 antibody at 20 μg/mL.

Gene/Protein Information For SCO1 (Source: Uniprot.org, NCBI)

Alternative Names

protein SCO1 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 1 (yeast); SCOD1SCO (cytochrome oxidase deficient, yeast) homolog 1 SCO1 MC4DN4, SCOD1 synthesis of cytochrome C oxidase 1 protein SCO1 homolog, mitochondrial|SCO cytochrome c oxidase assembly protein 1|SCO cytochrome oxidase deficient homolog 1|SCO1, cytochrome c oxidase assembly protein

For more info on SCO1, check out the SCO1 Infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for SCO1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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