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Product Info Summary
| SKU: | A00014 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Serine-protein kinase ATM ATM Antibody
SKU/Catalog Number
A00014
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Serine-protein kinase ATM ATM Antibody (Catalog # A00014). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Storage & Handling
ATM antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Serine-protein kinase ATM ATM Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00014)
Host
Rabbit
Contents
ATM Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
ATM antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human ATM. Thae immunogen is located within amino acids 2970 - 3020 of ATM.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A00014 is reactive to ATM in Human
Applications
A00014 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
350.687kDa
Background of ATM
DNA double strand breaks represent a major threat to an organism's genome. Eukaryotic cells have developed mechanisms that sense the presence this damage and initiate suitable responses that can include DNA repair, cell cycle delay, and programmed cell death. The ATM (mutated in Ataxia-Telangiectasia) protein kinase is activated following the formation of DNA double strand breaks, phosphorylating p53 and another kinase CHK2. This initiates a signaling cascade leading to the phosphorylation and inhibition of Cdc25, ultimately preventing cell cycle progression. In some cell types, such as the hemapoietic system, this leads to apoptosis instead of cell cycle arrest. Multiple isoforms of ATM are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ATM antibody can be used for detection of ATM by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 10 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of ATM in Daudi whole cell lysate with ATM antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of ATM in human lymph node tissue with ATM antibody at 2.5 μg/mL.
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Immunofluorescence of ATM in Human Lymph Node cells with ATM antibody at 10 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For ATM (Source: Uniprot.org, NCBI)
Gene Name
ATM
Full Name
Serine-protein kinase ATM
Weight
350.687kDa
Superfamily
PI3/PI4-kinase family
Alternative Names
AT mutated; A-T mutated; AT1; ATA; ataxia telangiectasia mutated (includes complementation groups A, C and D); ataxia telangiectasia mutatedATD; ATC; ATDC; ATE; ATM; DKFZp781A0353; EC 2.7.11.1; MGC74674; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1; TPLL ATM AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 ATM serine/threonine kinase serine-protein kinase ATM|A-T mutated|AT mutated|TEL1, telomere maintenance 1, homolog|ataxia telangiectasia mutated
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ATM, check out the ATM Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ATM: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Serine-protein kinase ATM ATM Antibody (A00014)
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No publications found for A00014
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Customer Reviews
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