Rabbit IgG polyclonal antibody for Suppressor of cytokine signaling 1(SOCS1) detection. Tested with WB, IHC-P in Human;Mouse;Rat. Cited in 2 publication(s).
Anti-SOCS1 Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
|Product Name||Anti-SOCS1 Antibody
See all SOCS-1 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for SOCS-1/SOCS1 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. SOCS-1/SOCS1 information: Molecular Weight: 23551 MW; Subcellular Localization: Nucleus . Cytoplasmic vesicle . Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3; Tissue Specificity: Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.|
|Cite This Product||Anti-SOCS1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1074)|
|Similar Products From
|Anti-SOCS1 Antibody may replace the following items: sc 7005 R|sc 7006|sc 9021.|
|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human SOCS1(197-211aa NPVLRDYLSSFPFQI), identical to the related mouse and rat sequences.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For SOCS1 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||8651|
|Species Of This Entry||Human|
|Protein Name||Suppressor of cytokine signaling 1|
|Alternative Names||SOCS-1|CIS1; Cish1; JAB; JABTec-interacting protein 3; JAK binding protein; JAK-binding protein; SOCS1; SOCS-1; SOCS-1CIS1; SSI-1; SSI-1CISH1; SSI1cytokine-inducible SH2 protein 1; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; suppressor of cytokine signaling 1; TIP3; TIP-3; TIP3Cish1|
|Post Tranlational Modifications||Phosphorylation; Methylation; Ubiquitination; Demethylation; Dephosphorylation; Reduction; Cleavage; Acetylation; Nitration; Isgylation; Deacetylation; Prenylation|
|Subcellular Localization||Nucleus. Cytoplasmic vesicle. Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.|
|Gene Location||16p13.13, on Chromasome 16, gene sequence: NC_000016.10 (11254417..11256182, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For SOCS1 (Source: Uniprot.org, NCBI)
|Protein Function||SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.|
|Tissue Specificity||Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.|
|Interacting Proteins||COMMD1; ELOC; ERBB2; RELA|
|Research Areas||Signal Transduction|
|Related Diseases||Neoplasms; Janiceps; Malignant Neoplasms; Inflammation; Carcinoma; Leukemia; Liver Carcinoma; Diabetes Mellitus; Autoimmune Reaction; Hepatitis; Colorectal Cancer; Colorectal Neoplasms; Liver Neoplasms; Cell Transformation, Neoplastic; Myeloid Leukemia; Microsatellite Instability; Virus Diseases; Infective Disorder; Innate Immune Response; Autoimmunity|
|Related Pathways||Methylation; Pathogenesis; Immune Response; Dna Methylation; Secretion; Cell Proliferation; Cytokine Production; Cell Activation; Inflammatory Response; Cell Growth; Cell Differentiation; Cell Death; T Cell Activation; Rna Interference; Localization; Translation; Cell Cycle; Gene Silencing; Cell Development; Demethylation|
|Background||Suppressor of cytokine signaling 1(SOCS1), also known as Jak-binding protein(JAB), is a negative regulator to a subset of protein-tyrosine kinases. This 211-amino acid protein has a molecular mass of about 23.5 kD. The TEC-binding region of SOCS1 resides in the N terminus. SOCS1 associates with Tec and suppresses its kinase activity. The SOCS1 gene is intronless and is mapped to on chromosome 16p13.13. SOCS1 regulates the JAK/STAT signal-transduction pathway. Moreover, it contributes to protection against hepatic injury and fibrosis, and may also protect against hepatocarcinogenesis.|
|Scientific References||PMID: 9266833 by Minamoto S., et al. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.|
PMID: 9341160 by Ohya K., et al. SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase.
Our Boster Quality Guarantee for Anti-SOCS1 Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: HT1080 Cell Lysate
Lane 2: COLO320 Cell Lysate
IHC(P): Rat Spleen Tissue
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
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Total number of citations: 2
|Yang M, Tian M, Zhang X, Xu J, Yang B, Yu J, Li F, Li Y, Li S, Li X. Oncotarget. 2017 Jun 16;8(57):96958-96969. doi: 10.18632/oncotarget.18555. eCollection 2017 Nov 14. Role of the JAK2/STAT3 signaling pathway in the pathogenesis of type 2 diabete...||PubMed ID 29228585|
|The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells||PubMed ID 20003295|
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Note: sample size takes longer to process, average 5-7 days.
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