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- Table of Contents
SOCS1 Antibodies
AND SOCS1 ELISA kits, SOCS1 Proteins
Many biological assays use antibodies to detect SOCS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SOCS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SOCS1 antibodies...
Designing a Western blot for SOCS1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SOCS1 Western Blot GuideDesigning an IHC experiment for SOCS1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SOCS1 IHC GuideSOCS1 Infographic by Boster Bio
All SOCS1 Products
Product
Figures
Specificity
Applications
Price
SOCS1 Overview
Facts about Suppressor of cytokine signaling 1.
Suppressor of cytokine signaling 1 (SOCS1)
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway.
Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine action.
Gene Information
| Human | |
|---|---|
| Gene Name: | SOCS1 |
| Uniprot: | O15524 |
| Entrez: | 8651 |
Family
| Belongs to: |
|---|
| SOCS1 family |
Alternative Names
CIS1; Cish1; JAB; JABTec-interacting protein 3; JAK binding protein; JAK-binding protein; SOCS1; SOCS-1; SOCS-1CIS1; SSI-1; SSI-1CISH1; SSI1cytokine-inducible SH2 protein 1; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; suppressor of cytokine signaling 1; TIP3; TIP-3; TIP3Cish1
Molecular Weight
Mass (kDA):
23.551 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.13 |
| Sequence: | 16; NC_000016.10 (11254417..11256182, complement) |
Tissue Specificity
Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
Subcellular Localizations
Nucleus. Cytoplasmic vesicle. Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
Diseases
- Neoplasms
- Janiceps
- Malignant Neoplasms
- Inflammation
- Carcinoma
- Leukemia
- Liver Carcinoma
- Diabetes Mellitus
- Autoimmune Reaction
- Hepatitis
- Colorectal Cancer
- Colorectal Neoplasms
- Liver Neoplasms
Interacting Proteins
- COMMD1
- ELOC
- ERBB2
- RELA
Pathways
- Methylation
- Pathogenesis
- Immune Response
- Dna Methylation
- Secretion
- Cell Proliferation
- Cytokine Production
- Cell Activation
- Inflammatory Response
- Cell Growth
- Cell Differentiation
- Cell Death
- T Cell Activation
PTMs
- Phosphorylation
- Methylation
- Ubiquitination
- Demethylation
- Dephosphorylation
- Reduction
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SOCS1
bosterbio.com/bosterbio-gene-info-cards/SOCS1
References
PMID: 9266833 by Minamoto S., et al. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.
PMID: 9341160 by Ohya K., et al. SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase.