Product Info Summary
SKU: | PA2135 |
---|---|
Size: | 100 μg/vial |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | WB |
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Product info
Product Name
Anti-Tafazzin/TAZ Antibody
View all Tafazzin/TAZ Antibodies
SKU/Catalog Number
PA2135
Size
100 μg/vial
Form
Lyophilized
Description
Boster Bio Anti-Tafazzin/TAZ Antibody catalog # PA2135. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Tafazzin/TAZ Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA2135)
Host
Rabbit
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human Tafazzin, identical to the related mouse and rat sequences.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins
Reactive Species
PA2135 is reactive to TAZ in Human, Mouse, Rat
Applications
PA2135 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
60 kDa
Calculated molecular weight
33.459kDa
Background of Tafazzin/TAZ
Tafazzin is a protein that in humans is encoded by the TAFAZZIN gene. This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Innovating Scientists Reward
If you are the first to review this product, or if you have results for a special sample, species or application this product is not validated in, share your results with us and receive product credits you can use towards any Boster products! Applicable to all scientists worldwide.
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Assay dilution & Images
Reconsitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
Validation Images & Assay Conditions
Click image to see more details
Anti-Tafazzin/TAZ antibody, PA2135, Western blotting
Lane 1: Rat Skeletal Muscle Tissue Lysate
Lane 2: Rat Heart Tissue Lysate
Lane 3: Rat Liver Tissue Lysate
Lane 4: HELA Cell Lysate
Lane 5: SMMC Cell Lysate
Lane 6: SCG Cell Lysate
Protein Target Info & Infographic
Gene/Protein Information For TAZ (Source: Uniprot.org, NCBI)
Gene Name
TAZ
Full Name
Tafazzin
Weight
33.459kDa
Superfamily
taffazin family
Alternative Names
BTHSEFE; cardiomyopathy, dilated 3A (X-linked); CMD3A; EFE2FLJ27390; G4.5endocardial fibroelastosis 2; LVNCX; Protein G4.5; tafazzin; Taz1; XAP-2 TAFAZZIN BTHS, CMD3A, EFE, EFE2, G4.5, LVNCX, TAZ, Taz1 tafazzin, phospholipid-lysophospholipid transacylase tafazzin|protein G4.5
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TAZ, check out the TAZ Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TAZ: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Tafazzin/TAZ Antibody (PA2135)
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No publications found for PA2135
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Customer Reviews
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Customer Q&As
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Find answers in Q&As, reviews.
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4 Customer Q&As for Anti-Tafazzin/TAZ Antibody
Question
We are currently using anti-Tafazzin/TAZ antibody PA2135 for human tissue, and we are content with the WB results. The species of reactivity given in the datasheet says human, mouse, rat. Is it possible that the antibody can work on canine tissues as well?
Verified Customer
Verified customer
Asked: 2019-11-18
Answer
The anti-Tafazzin/TAZ antibody (PA2135) has not been validated for cross reactivity specifically with canine tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in canine you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2019-11-18
Question
We have observed staining in mouse small intestine peyer's patch. Any tips? Is anti-Tafazzin/TAZ antibody supposed to stain small intestine peyer's patch positively?
Verified Customer
Verified customer
Asked: 2019-07-03
Answer
From literature small intestine peyer's patch does express TAZ. From Uniprot.org, TAZ is expressed in small intestine peyer's patch, heart skeletal muscle, among other tissues. Regarding which tissues have TAZ expression, here are a few articles citing expression in various tissues:
Heart, and Skeletal muscle, Pubmed ID: 8630491
Boster Scientific Support
Answered: 2019-07-03
Question
Our team were content with the WB result of your anti-Tafazzin/TAZ antibody. However we have seen positive staining in small intestine peyer's patch isoform 1: membrane using this antibody. Is that expected? Could you tell me where is TAZ supposed to be expressed?
Verified Customer
Verified customer
Asked: 2019-06-17
Answer
According to literature, small intestine peyer's patch does express TAZ. Generally TAZ expresses in isoform 1: membrane. Regarding which tissues have TAZ expression, here are a few articles citing expression in various tissues:
Heart, and Skeletal muscle, Pubmed ID: 8630491
Boster Scientific Support
Answered: 2019-06-17
Question
you antibody using your anti-Tafazzin/TAZ antibody for mitochondrial respiratory chain complex i assembly studies. Has this antibody been tested with western blotting on rat heart tissue? We would like to see some validation images before ordering.
F. Carter
Verified customer
Asked: 2015-02-12
Answer
Thanks for your inquiry. This PA2135 anti-Tafazzin/TAZ antibody is validated on rat heart tissue, skeletal muscle tissue, tissue lysate, liver tissue, hela cell lysate, smmc cell lysate, scg cell lysate. It is guaranteed to work for WB in human, mouse, rat. Our Boster guarantee will cover your intended experiment even if the sample type has not been be directly tested.
Boster Scientific Support
Answered: 2015-02-12