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Product Info Summary
| SKU: | A04801 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-TMEM16B ANO2 Antibody
SKU/Catalog Number
A04801
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TMEM16B ANO2 Antibody (Catalog # A04801). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TMEM16B antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-TMEM16B ANO2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04801)
Host
Rabbit
Contents
TMEM16B Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
Clone: SK7
Isotype
IgG
Immunogen
TMEM16B antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human TMEM16B. The immunogen is located within the first 50 amino acids of TMEM16B.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of EPAC2 are known to exist; this antibody will detect only the larger isoform. EPAC2 antibody is predicted to not cross-react with EPAC2
Reactive Species
A04801 is reactive to ANO2 in Human, Mouse, Rat
Applications
A04801 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
113.969kDa
Background of ANO2
Calcium-activated chloride channels (CaCC) are present in many cell types and mediate physiological functions such as epithelial secretion, sensory signal transduction, and smooth muscle contraction. Subunits of these CaCC's include the transmembrane proteins TMEM16A and TMEM16B. TMEM16B is predicted to have eight transmembrane domains with both the amino and carboxy termini in the cytoplasm and is expressed in several tissues including olfactory sensory neurons as well as photoreceptors in mammalian retina. Like TMEM16A, TMEM16B is thought to form at least part of CaCC's but has different biophysical characteristics such as voltage dependence and unitary conductance.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TMEM16B antibody can be used for detection of TMEM16B by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TMEM16B in human small intestine tissue lysate with TMEM16B antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of TMEM16B in human brain tissue with FRMPD4 antibody at 5 μg/mL.
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Immunofluorescence of TMEM16B in Human Brain cells with TMEM16B antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For ANO2 (Source: Uniprot.org, NCBI)
Gene Name
ANO2
Full Name
Anoctamin-2
Weight
113.969kDa
Superfamily
anoctamin family
Alternative Names
Anoctamin-2 ANO2 C12orf3, TMEM16B anoctamin 2 anoctamin-2|anoctamin 2, calcium activated chloride channel|transmembrane protein 16B (eight membrane-spanning domains)
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ANO2, check out the ANO2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ANO2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TMEM16B ANO2 Antibody (A04801)
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No publications found for A04801
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Customer Reviews
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