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Product Info Summary
| SKU: | A08960 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-TREX2 Antibody
SKU/Catalog Number
A08960
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TREX2 Antibody (Catalog # A08960). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TREX2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-TREX2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08960)
Host
Rabbit
Contents
TREX2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TREX2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TREX2. The immunogen is located within the last 50 amino acids of TREX2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This TREX2 antibody will not cross-react with the related protein TREX1.
Reactive Species
A08960 is reactive to TREX2 in Human, Mouse, Rat
Applications
A08960 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
25.922kDa
Background of TREX2
TREX2 is one of two major human 3' to 5' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TREX2 antibody can be used for detection of TREX2 by Western blot at 2.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TREX2 in rat liver tissue lysate with TREX2 antibody at 2.5 μg/mL.
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Immunohistochemistry of TREX2 in human liver tissue with TREX2 antibody at 2.5 μg/mL.
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Immunofluorescence of TREX2 in Human Liver cells with TREX2 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TREX2 (Source: Uniprot.org, NCBI)
Gene Name
TREX2
Full Name
Three prime repair exonuclease 2
Weight
25.922kDa
Superfamily
exonuclease superfamily
Alternative Names
3'-5' exonuclease TREX2; EC 3.1.11.2; three prime repair exonuclease 2,3'-5' exonuclease TREX2 long form TREX2 three prime repair exonuclease 2 three prime repair exonuclease 2|3-5 exonuclease TREX2 long form
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TREX2, check out the TREX2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TREX2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TREX2 Antibody (A08960)
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