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Product Info Summary
| SKU: | A12617 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-UCMA Antibody
SKU/Catalog Number
A12617
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-UCMA Antibody (Catalog # A12617). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.
Storage & Handling
UCMA antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-UCMA Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A12617)
Host
Rabbit
Contents
UCMA Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
Clone: SK7
Isotype
IgG
Immunogen
UCMA antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human UCMA. The immunogen is located within the last 50 amino acids of UCMA.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms of N4BP1 are known to exist; this antibody will only detect the longest isoform.
Reactive Species
A12617 is reactive to Ucma in Human, Mouse
Applications
A12617 is guaranteed for ELISA, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
16.579kDa
Background of Ucma
UCMA is a secreted cartilage-specific protein that was discovered in a screen for differentially expressed genes in retinoic acid-treated mouse chondrocytes. It was also identified in a human chondrocyte EST screen for candidate genes of skeletal dysplasias. UCMA expression is thought to parallel that of collagen II with its expression decreasing with maturation chrondrocytes mature. UCMA is processed by a furin-like protease into two fragments, an amino-terminal fragment and a carboxy-terminal fragment (UCMA-C). Application of recombinant UCMA-C to primary osteoblasts, mesenchymal stem cells, and MC3T3-E1 pre-osteoblasts interferes with their osteogenic differentiation, but does not affect expression of chondrocyte-specific genes or chondrocyte proliferation, suggesting that UCMA may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells. At least two isoforms of UCMA are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
UCMA antibody can be used for detection of UCMA by Western blot at 2.5 - 5 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of UCMA in SW1353 cell lysate with UCMA antibody at 2.5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For Ucma (Source: Uniprot.org, NCBI)
Gene Name
Ucma
Full Name
Unique cartilage matrix-associated protein
Weight
16.579kDa
Superfamily
UCMA family
Alternative Names
C10orf49; chromosome 10 open reading frame 49; Gla-rich protein; GRP; unique cartilage matrix-associated protein; upper zone of growth plate and cartilage matrix associated Ucma|1110017I16Rik, AW121955, Grp|upper zone of growth plate and cartilage matrix associated|unique cartilage matrix-associated protein|Gla-rich protein|upper zone of growth plate and cartilage matrix associated protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Ucma, check out the Ucma Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Ucma: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-UCMA Antibody (A12617)
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No publications found for A12617
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Customer Reviews
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