Anti-XRCC4 Antibody Picoband™

XRCC4 antibody

Boster Bio Anti-XRCC4 Antibody Picoband™ catalog # PB9908. Tested in IHC, WB applications. This antibody reacts with Human.

Product Info Summary

SKU: PB9908
Size: 100 μg/vial
Reactive Species: Human
Host: Rabbit
Application: IHC, WB

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Product Name

Anti-XRCC4 Antibody Picoband™

View all XRCC4 Antibodies

SKU/Catalog Number

PB9908

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-XRCC4 Antibody Picoband™ catalog # PB9908. Tested in IHC, WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-XRCC4 Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # PB9908)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human XRCC4, different from the related mouse sequence by four amino acids.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins.

Reactive Species

PB9908 is reactive to XRCC4 in Human

Applications

PB9908 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

55 kDa

Calculated molecular weight

38.287kDa

Background of XRCC4

DNA repair protein XRCC4, also known as X-ray repair cross-complementing protein 4 or XRCC4, is a protein that in humans is encoded by the XRCC4 gene. In addition to humans, the XRCC4 protein is also expressed in many other metazoans, fungi and in plants. The X-ray repair cross-complementing protein 4 is one of several coreproteins involved in the non-homologous end joining (NHEJ) pathway to repair DNA double strand breaks (DSBs). Since XRCC4 is the key protein that enables interaction of LigIV to damaged DNA and therefore ligation of the ends, mutations in the XRCC4 gene were found to cause embryonic lethality in mice and developmental inhibition and immunodeficiency in humans. Furthermore, certain mutations in the XRCC4 gene are associated with an increased risk of cancer.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human

Validation Images & Assay Conditions

Gene/Protein Information For XRCC4 (Source: Uniprot.org, NCBI)

Gene Name

XRCC4

Full Name

DNA repair protein XRCC4

Weight

38.287kDa

Superfamily

XRCC4 family

Alternative Names

complementing defective, repair in Chinese hamster; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross-complementing protein 4 XRCC4 SSMED X-ray repair cross complementing 4 DNA repair protein XRCC4|X-ray repair complementing defective repair in Chinese hamster cells 4

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on XRCC4, check out the XRCC4 Infographic

XRCC4 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for XRCC4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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6 Customer Q&As for Anti-XRCC4 Antibody Picoband™

Question

I was wanting to use your anti-XRCC4 antibody for WB for human bone marrow on frozen tissues, but I want to know if it has been tested for this particular application. Has this antibody been tested and is this antibody a good choice for human bone marrow identification?

Verified Customer

Verified customer

Asked: 2019-09-25

Answer

You can see on the product datasheet, PB9908 anti-XRCC4 antibody has been tested for IHC, WB on human tissues. We have an innovator award program that if you test this antibody and show it works in human bone marrow in IHC-frozen, you can get your next antibody for free.

Boster Scientific Support

Answered: 2019-09-25

Question

See attached the WB image, lot number and protocol we used for bone marrow using anti-XRCC4 antibody PB9908. Please let me know if you require anything else.

Verified Customer

Verified customer

Asked: 2019-09-17

Answer

Thank you very much for the data. Our lab team are working to resolve this as quickly as possible, and we appreciate your patience and understanding! You have provided everything we needed. Please let me know if there is anything you need in the meantime.

Boster Scientific Support

Answered: 2019-09-17

Question

Is there a BSA free version of anti-XRCC4 antibody PB9908 available?

Verified Customer

Verified customer

Asked: 2019-08-08

Answer

Thanks for your recent telephone inquiry. I can confirm that some lots of this anti-XRCC4 antibody PB9908 are BSA free. For now, these lots are available and we can make a BSA free formula for you free of charge. It will take 3 extra days to prepare. If you require this antibody BSA free again in future, please do not hesitate to contact me and I will be pleased to check which lots we have in stock that are BSA free.

Boster Scientific Support

Answered: 2019-08-08

Question

Is this PB9908 anti-XRCC4 antibody reactive to the isotypes of XRCC4?

Verified Customer

Verified customer

Asked: 2018-02-08

Answer

The immunogen of PB9908 anti-XRCC4 antibody is A synthetic peptide corresponding to a sequence at the N-terminus of human XRCC4 (49-75aa ESEISQEADDMAMEKGKYVGELRKALL), different from the related mouse sequence by four amino acids. Could you tell me which isotype you are interested in so I can help see if the immunogen is part of this isotype?

Boster Scientific Support

Answered: 2018-02-08

Question

We are interested in to test anti-XRCC4 antibody PB9908 on human bone marrow for research purposes, then I may be interested in using anti-XRCC4 antibody PB9908 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?

Verified Customer

Verified customer

Asked: 2017-07-27

Answer

The products we sell, including anti-XRCC4 antibody PB9908, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.

Boster Scientific Support

Answered: 2017-07-27

Question

We are currently using anti-XRCC4 antibody PB9908 for human tissue, and we are content with the IHC results. The species of reactivity given in the datasheet says human. Is it true that the antibody can work on canine tissues as well?

R. Dhar

Verified customer

Asked: 2014-12-03

Answer

The anti-XRCC4 antibody (PB9908) has not been validated for cross reactivity specifically with canine tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in canine you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2014-12-03

Order DetailsPrice
PB9908

100μg

$370
PB9908-10ug

10μg sample (liquid)

$99
PB9908-Biotin

100 μg Biotin conjugated

$570
PB9908-Cy3

100 μg Cy3 conjugated

$570
PB9908-Dylight488

100 μg Dylight488 conjugated

$570
PB9908-Dylight550

100 μg Dylight550 conjugated

$570
PB9908-Dylight594

100 μg Dylight594 conjugated

$570
PB9908-FITC

100 μg FITC conjugated

$570
PB9908-HRP

100 μg HRP conjugated

$570
PB9908-APC

100 μg APC conjugated

$670
PB9908-PE

100 μg PE conjugated

$670
PB9908-carrier-free

Carrier Free

$370

More conjugates/formats

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PB9908
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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