DNA repair protein XRCC4 Antibodies

AND XRCC4 ELISA kits, DNA repair protein XRCC4 Proteins

Many biological assays use antibodies to detect DNA repair protein XRCC4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNA repair protein XRCC4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNA repair protein XRCC4 antibodies...

We validate the specificity of these antibodies to DNA repair protein XRCC4 by testing them on tissues known to express XRCC4 positively and negatively. Browse below to find the XRCC4 antibody that suites your experiment. We have 8 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for DNA repair protein XRCC4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the XRCC4 Western Blot Guide

Designing an IHC experiment for DNA repair protein XRCC4? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the XRCC4 IHC Guide

XRCC4 Infographic by Boster Bio

All XRCC4 Products

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Product

Figures

Specificity

Applications

Price

Anti-CPT1B Antibody Picoband®

1 Citations

Western blot analysis of CPT1B using anti-CPT1B antibody (A03558)

IF analysis of CPT1B using anti-CPT1B antibody (A03558)

Flow Cytometry analysis of Hela cells using anti-CPT1B antibody (A03558)

Human, Monkey, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A03558
100 μg/vial

Anti-RAP1GAP Antibody Picoband®

Western blot analysis of RAP1GAP using anti-RAP1GAP antibody (A03561-2)

IHC analysis of RAP1GAP using anti-RAP1GAP antibody (A03561-2)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A03561-2
100 µg/vial

Anti-XLF/NHEJ1 Picoband® Antibody

Western blot analysis of NHEJ1 using anti-NHEJ1 antibody (A03552-3)

IHC analysis of NHEJ1 using anti-NHEJ1 antibody (A03552-3)

Human, Mouse

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A03552-3
100 μg/vial

Anti-XRCC4 Antibody Picoband®

Western blot analysis of XRCC4 using anti-XRCC4 antibody (PB9908)

IHC analysis of XRCC4 using anti-XRCC4 antibody (PB9908)

Human

IHC, WB

$370
Cat # PB9908
100 μg/vial

Anti-XRCC4 Antibody Picoband®

Western blot analysis of XRCC4 using anti-XRCC4 antibody (A00787-2)

IHC analysis of XRCC4 using anti-XRCC4 antibody (A00787-2)

Human

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A00787-2
100 μg/vial

Anti-Xrcc4 Antibody Picoband®

Western blot analysis of XRCC4 using anti-XRCC4 antibody (A00787-1)

IHC analysis of XRCC4 using anti-XRCC4 antibody (A00787-1)

Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A00787-1
100 μg/vial

XRCC4 Colorimetric Cell-Based ELISA Kit

Western blot analysis of extracts from COLO205 cells

Human

ELISA

$480
Cat # EKC1605
1 kit, containing one 96-well plate and all necessary reagents

XRCC4 (NM_003401) Human Over-expression Lysate

XRCC4 Human Over-expression Lysates NM_003401

Human

$628
Cat # LS007518
20 µg, 100 µg

XRCC4 Overview

Facts about DNA repair protein XRCC4.

XRCC4 3D structure. Source: alphafold

DNA repair protein XRCC4 (XRCC4)

Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4).

The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enriches the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of this DNA-dependent protein kinase complex DNA-PK to those DNA ends.

Gene Information

Human
Gene Name:	XRCC4
Uniprot:	Q13426
Entrez:	7518

Family

Belongs to:

XRCC4 family

Alternative Names

complementing defective, repair in Chinese hamster; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross-complementing protein 4

Molecular Weight

Mass (kDA):
38.287 kDA

Genomic Context


Human

Location:	5q14.2
Sequence:	5; NC_000005.10 (83077409..83370333)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Genomic Instability
Chromosomal Translocation
Carcinogenesis
Malignant Neoplasm Of Breast
Immunologic Deficiency Syndromes
Mammary Neoplasms
Severe Combined Immunodeficiency
Lymphoma
Chromosome Breakage
Cytogenetic Abnormality
Ataxia

Ataxia Telangiectasia
Cell Transformation, Neoplastic
Leukemia
Malignant Neoplasm Of Lung
Carcinoma
Lung Neoplasms
Malignant Neoplasm Of Urinary Bladder

Interacting Proteins

APLF
APTX
ASTE1
BIN1
FAM9B

LIG4
NHEJ1
PNKP
XRCC6

Pathways

Dna Repair
V(d)j Recombination
Double-strand Break Repair
Cell Cycle
Cell Death
Dna Ligation
Senescence
Dna Replication
Pathogenesis
Rna Interference
Transposition
S Phase
Localization

Mismatch Repair
Cell Cycle Checkpoint
Dna Integration
Hypersensitivity
Cellular Senescence
Aging
Telomere Maintenance

PTMs

Phosphorylation
Cleavage
Acetylation

Deamination
Dephosphorylation
Methylation

Ubiquitination

Research Areas

Cancer
DNA Double Strand Break Repair
DNA Repair
Homologous Recombination
Non-homologous end-joining

Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/XRCC4

References

PMID: 8548796 by Li Z., et al. The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination.

PMID: 9259561 by Critchlow S.E., et al. Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV.