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- Table of Contents
Acetyl-CoA carboxylase 2 Antibodies
AND ACACB ELISA kits, Acetyl-CoA carboxylase 2 Proteins
Many biological assays use antibodies to detect Acetyl-CoA carboxylase 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Acetyl-CoA carboxylase 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Acetyl-CoA carboxylase 2 antibodies...
Designing a Western blot for Acetyl-CoA carboxylase 2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ACACB Western Blot GuideDesigning an IHC experiment for Acetyl-CoA carboxylase 2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ACACB IHC GuideACACB Infographic by Boster Bio
All ACACB Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # A03668-2
100 μg/vial
Cat # A03668-2
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A03673-1
100 μg/vial
Cat # A03673-1
100 μg/vial
Human, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A03671-4
100 μg/vial
Cat # A03671-4
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M03668-1
20μL, 40μL, 100μL, 200μL
Cat # M03668-1
20μL, 40μL, 100μL, 200μL
ACACB Overview
Facts about Acetyl-CoA carboxylase 2.
Acetyl-CoA carboxylase 2 (ACACB)
Catalyzes the ATP-dependent carboxylation of acetyl-CoA into malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | ACACB |
| Uniprot: | O00763 |
| Entrez: | 32 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ACC2ACC-beta; ACCBacetyl-CoA carboxylase 2; acetyl-CoA carboxylase beta; acetyl-Coenzyme A carboxylase beta; EC 6.4.1.2; HACC275
Molecular Weight
Mass (kDA):
276.541 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.11 |
| Sequence: | 12; NC_000012.12 (109112666..109268226) |
Tissue Specificity
Widely expressed with highest levels in heart, skeletal muscle, liver, adipose tissue, mammary gland, adrenal gland and colon (PubMed:9099716). Isoform 3 is expressed in skeletal muscle, adipose tissue and liver (at protein level) (PubMed:19190759). Isoform 3 is detected at high levels in adipose tissue with lower levels in heart, liver, skeletal muscle and testis (PubMed:19190759).
Subcellular Localizations
Mitochondrion.
Diseases
- Diabetes Mellitus
- Obesity
- Diabetes Mellitus, Non-insulin-dependent
- Insulin Resistance
- Insulin Sensitivity
- Steatohepatitis
- Steatosis
- Fatty Liver
- Kidney Diseases
- Diabetic Nephropathy
- Inflammation
- Malignant Neoplasms
- Neoplasms
Interacting Proteins
- HLCS
- Mid1ip1
Pathways
- Fatty Acid Oxidation
- Pathogenesis
- Glycolysis
- Secretion
- Muscle Contraction
- Gluconeogenesis
- Glucose Homeostasis
- Cell Proliferation
- Fatty Acid Beta-oxidation
- Lipid Oxidation
- Transport
- Hibernation
- Cell Activation
PTMs
- Oxidation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACACB
bosterbio.com/bosterbio-gene-info-cards/ACACB
References
PMID: 9099716 by Abu-Elheiga L., et al. Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms.
PMID: 16854592 by Cheng D., et al. Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes.