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- Table of Contents
ACO1 Antibodies
AND ACO1 ELISA kits, ACO1 Proteins
Many biological assays use antibodies to detect ACO1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ACO1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ACO1 antibodies...
Designing a Western blot for ACO1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ACO1 Western Blot GuideACO1 Infographic by Boster Bio
All ACO1 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02781-1
100 μg/vial
Cat # A02781-1
100 μg/vial
Human, Mouse, Rat
IF, ICC, WB
$370
Cat # M02781
100 μl
Cat # M02781
100 μl
Human, Monkey, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$335
Cat # P30450
100ul
Cat # P30450
100ul
ACO1 Overview
Facts about Cytoplasmic aconitate hydratase.
Cytoplasmic aconitate hydratase (ACO1)
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high.
Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low.
Gene Information
| Human | |
|---|---|
| Gene Name: | ACO1 |
| Uniprot: | P21399 |
| Entrez: | 48 |
Family
| Belongs to: |
|---|
| aconitase/IPM isomerase family |
Alternative Names
aconitase 1, soluble; Aconitase; aconitate hydratase; Citrate hydro-lyase; cytoplasmic aconitate hydratase; EC 4.2.1; EC 4.2.1.3; Ferritin repressor protein; IREB1IREBP1; IRE-BP 1; IREBP; Iron regulatory protein 1; iron-responsive element binding protein 1; Iron-responsive element-binding protein 1; IRP1ACONS
Molecular Weight
Mass (kDA):
98.399 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p21.1 |
| Sequence: | 9; NC_000009.12 (32384603..32454769) |
Subcellular Localizations
Cytoplasm.
Diseases
- Melanoma
- Neoplasms
- Malignant Paraganglionic Neoplasm
- Neurodegenerative Disorders
- Medium-chain Acyl-coenzyme A Dehydrogenase Deficiency
- Cholangiocarcinoma
- Classical Galactosemia
- Mutation Abnormality
- Mitochondrial Diseases
- Hypoxia
- Atrophic Retina
- Carcinoma
Interacting Proteins
- NEB
- SGCG
Pathways
- Transport
- Gene Silencing
- Fruit Ripening
- Senescence
- Glyoxylate Cycle
- Fruit Development
- Immune Response
- Virulence
- Cell Cycle
- Metaphase
- Pathogenesis
- Rna Interference
- Cell Adhesion
PTMs
- Phosphorylation
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACO1
bosterbio.com/bosterbio-gene-info-cards/ACO1
References
PMID: 1738601 by Hirling H., et al. Expression of active iron regulatory factor from a full-length human cDNA by in vitro transcription/translation.
PMID: 2172968 by Rouault T.A., et al. Cloning of the cDNA encoding an RNA regulatory protein -- the human iron-responsive element-binding protein.
1 Publications of Boster ACO1 Antibodies & ELISA Kits
- PubMed ID: 30922643, The impact of chronic endometritis on endometrial fibrosis and reproductive prog...
*More publications can be found for each product on its corresponding product page