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- Table of Contents
Activin receptor type-2A Antibodies
AND ACVR2A ELISA kits, Activin receptor type-2A Proteins
Many biological assays use antibodies to detect Activin receptor type-2A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Activin receptor type-2A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Activin receptor type-2A antibodies...
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ACVR2A Infographic by Boster Bio
All ACVR2A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB10027
100 μg/vial
Cat # PB10027
100 μg/vial
Human, Mouse, Rat
IHC, WB
$523
Cat # M04770
100 µl
Cat # M04770
100 µl
Human
$628
Cat # LS000092
20 µg, 100 µg
Cat # LS000092
20 µg, 100 µg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M04770-2
100 μg
Cat # M04770-2
100 μg
ACVR2A Overview
Facts about Activin receptor type-2A.
Activin receptor type-2A (ACVR2A)
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.
Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | ACVR2A |
| Uniprot: | P27037 |
| Entrez: | 92 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
activin A receptor, type II; activin A receptor, type IIA; Activin receptor type IIA; activin receptor type-2A; Activin RIIA; ActivinRIIA; ACTRII; ACTRIIA; ACVR2A; ACVR2ACTR-IIA; AVR2A; EC 2.7.11; EC 2.7.11.30
Molecular Weight
Mass (kDA):
57.848 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q22.3-q23.1 |
| Sequence: | 2; NC_000002.12 (147844517..147930827) |
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Pre-eclampsia
- Malignant Neoplasm Of Breast
- Severe Combined Immunodeficiency
- Dysequilibrium Syndrome
- Trisomy
- Teratoma
- Multiple Myeloma
- Disorder Of Pregnancy
- Immunologic Deficiency Syndromes
- Fibrosis
Pathways
- Cell Proliferation
- Cell Growth
- Pathogenesis
- Osteoblast Differentiation
- Brain Development
- Pigmentation
- Ossification
- Limb Development
- Cell Division
- Regulation Of Osteoblast Differentiation
- Positive Regulation Of Osteoblast Differentiation
- Meiosis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACVR2A
bosterbio.com/bosterbio-gene-info-cards/ACVR2A
References
PMID: 1311955 by Matzuk M.M., et al. Cloning of the human activin receptor cDNA reveals high evolutionary conservation.
PMID: 1314589 by Donaldson C.J., et al. Molecular cloning and binding properties of the human type II activin receptor.