Activin receptor type-2A (ACVR2A)

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.

Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).