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- Table of Contents
Activin receptor type-2A Antibodies
AND ACVR2A ELISA kits, Activin receptor type-2A Proteins
Many biological assays use antibodies to detect Activin receptor type-2A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Activin receptor type-2A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Activin receptor type-2A antibodies...
Designing a Western blot for Activin receptor type-2A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ACVR2A Western Blot GuideACVR2A Infographic by Boster Bio
All ACVR2A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # PB10027
100 μg/vial
Cat # PB10027
100 μg/vial
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M04770-2
100 μg
Cat # M04770-2
100 μg
Human, Mouse, Rat
IHC, WB
$523
Cat # M04770
100 µl
Cat # M04770
100 µl
Human
$628
Cat # LS000092
20 µg, 100 µg
Cat # LS000092
20 µg, 100 µg
ACVR2A Overview
Facts about Activin receptor type-2A.
Activin receptor type-2A (ACVR2A)
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.
Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | ACVR2A |
| Uniprot: | P27037 |
| Entrez: | 92 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
activin A receptor, type II; activin A receptor, type IIA; Activin receptor type IIA; activin receptor type-2A; Activin RIIA; ActivinRIIA; ACTRII; ACTRIIA; ACVR2A; ACVR2ACTR-IIA; AVR2A; EC 2.7.11; EC 2.7.11.30
Molecular Weight
Mass (kDA):
57.848 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q22.3-q23.1 |
| Sequence: | 2; NC_000002.12 (147844517..147930827) |
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Pre-eclampsia
- Malignant Neoplasm Of Breast
- Severe Combined Immunodeficiency
- Dysequilibrium Syndrome
- Trisomy
- Teratoma
- Multiple Myeloma
- Disorder Of Pregnancy
- Immunologic Deficiency Syndromes
- Fibrosis
Pathways
- Cell Proliferation
- Cell Growth
- Pathogenesis
- Osteoblast Differentiation
- Brain Development
- Pigmentation
- Ossification
- Limb Development
- Cell Division
- Regulation Of Osteoblast Differentiation
- Positive Regulation Of Osteoblast Differentiation
- Meiosis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACVR2A
bosterbio.com/bosterbio-gene-info-cards/ACVR2A
References
PMID: 1311955 by Matzuk M.M., et al. Cloning of the human activin receptor cDNA reveals high evolutionary conservation.
PMID: 1314589 by Donaldson C.J., et al. Molecular cloning and binding properties of the human type II activin receptor.