This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
ALOX12 Antibodies
AND ALOX12 ELISA kits, ALOX12 Proteins
Many biological assays use antibodies to detect ALOX12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ALOX12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ALOX12 antibodies...
Designing a Western blot for ALOX12? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ALOX12 Western Blot GuideALOX12 Infographic by Boster Bio
All ALOX12 Products
Product
Figures
Specificity
Applications
Price
Anti-12 Lipoxygenase/ALOX12 Antibody Picoband®
1 Citations
Mouse, Rat
WB
$370
Cat # A02275-1
100 μg/vial
Cat # A02275-1
100 μg/vial
Human, Mouse
IHC, WB
$523
Cat # M02275
100 µl
Cat # M02275
100 µl
Human
$628
Cat # LS000239
20 µg, 100 µg
Cat # LS000239
20 µg, 100 µg
ALOX12 Overview
Facts about Arachidonate 12-lipoxygenase, 12S-type.
Arachidonate 12-lipoxygenase, 12S-type (ALOX12)
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids producing a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid.
Has a dual activity since it also converts leukotriene A4/LTA4 into the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it modulates distinct biological processes including platelet activation.
Gene Information
| Human | |
|---|---|
| Gene Name: | ALOX12 |
| Uniprot: | P18054 |
| Entrez: | 239 |
Family
| Belongs to: |
|---|
| lipoxygenase family |
Alternative Names
12(S)-lipoxygenase; 12-LOX; 12S-lipoxygenase; 12S-LOXarachidonate 12-lipoxygenase, 12S-type; arachidonate 12-lipoxygenase; EC 1.13.11; EC 1.13.11.31; LOG12; platelet 12-LOX; platelet-type 12-lipoxygenase; Platelet-type lipoxygenase 12
Molecular Weight
Mass (kDA):
75.694 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.1 |
| Sequence: | 17; NC_000017.11 (6993791..7010754) |
Tissue Specificity
Expressed in vascular smooth muscle cells.
Subcellular Localizations
Cytoplasm, cytosol. Membrane. Membrane association is stimulated by EGF.
Diseases
- Dysequilibrium Syndrome
- Atherosclerosis
- Inflammation
- Malignant Neoplasms
- Ichthyoses
- Congenital Ichthyosis
- Exfoliative Dermatitis
- Cardiovascular Diseases
- Ichthyosiform Erythroderma, Congenital
- Osteoporosis
- Cerebrovascular Accident
- Leukemia
- Kidney Diseases
Interacting Proteins
- KRT5
- LMNA
Pathways
- Dna Methylation
- Methylation
- Cell Proliferation
- Transport
- Keratinization
- Menopause
- Ovulation
- Secretion
- Protein Phosphorylation
- Dna Hypomethylation
- Inflammatory Response
- Menstruation
- Axon Ensheathment
PTMs
- Methylation
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ALOX12
bosterbio.com/bosterbio-gene-info-cards/ALOX12
References
PMID: 2244907 by Yoshimoto T., et al. Molecular cloning and expression of human arachidonate 12- lipoxygenase.
PMID: 2377602 by Funk C.D., et al. Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase.